October 2013

Evaluation of hypoglycaemic and antihyperglycaemic activity of methanolic wholeplant extract of Schwenckia americana (Solanacae) in normal and alloxan-induced diabetic rats

Powdered whole plant of Schwenckia americana (family Solanacae) is used traditionally (in combination with other herbs) for treating diabetes mellitus in Northern Nigeria. Therefore, in the current study, the traditional claim was evaluated by testing the effects of methanolic extract of S. americana whole plant on blood glucose in normal, alloxan-induced sub-diabetic and alloxan-induced diabetic rats. The median lethal...

Author(s): Bello, S. O., Chika, A., Jimoh, A. O., Abubakar, K. and Adebisi, I.

October 2013

Application of ĸ-carrageenan as a sustained release matrix in floating tablets containing sodium salicylate

The main aim of the present investigation was to develop sustained release (SR) floating drug delivery system (FDDS) of sodium salicylate using k-carrageenan as the sustained release matrix. Varying w/w concentration ratios of drug and polymer dispersion ranging from 1:0 to 1:1 were selected from the preliminary trials for this investigation made from batches granulated with isopropyl alcohol containing, in addition,...

Author(s): Ikechukwu V. Onyishi, Salome Amarachi Chime and Elvis Egwu

October 2013

Acute and sub-acute toxicity of Terminalia fagifolia Mart. & Zucc. (Combretaceae) in rodents

Terminalia fagifolia Mart & Zucc is a typical plant from Brazilian savanna, whose stem bark is used in popular medicine for relief of gastrointestinal discomfort. A phytochemical study showed the presence of large amounts of antioxidants (flavonoids and triterpenes). In acute toxicity tests, five groups of female mice were orally treated with stem bark extract from T. fagifolia or fractions by gavage at doses 2...

Author(s): Melka Coêlho Sá, Jamylla Mirck Guerra de Oliveira, Silvana Maria Medeiros de Sousa Silva, Paulo Alex Bezerra Sales, Marina Rebeca Soares Carneiro de Sousa, Tatiane Novaes Costa, Paulo Humberto Moreira Nunes and Amilton Paulo Raposo Costa

October 2013

Biochemical investigations into the effects of co-administration of ciprofloxacin and nicosan

The biochemical effects of Ciprofloxacin, a wide spectrum antibiotic, co-administered with Nicosan, an antisickling phytomedicine was analyzed for their possible drug interaction. Using standard methods for biochemical, haematological and antioxidant assays, our findings showed that Ciprofloxacin administration gave rise to increase in oxidative radical production, whereas Nicosan administration had...

Author(s): I. M. Fatai, N. O. A. Imaga and G. O. Gbenle