African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2281

Full Length Research Paper

In vitro antiviral activities under cytotoxic doses against herpes simples type-1 and parainfluensa-3 viruses of Cicer arietinum L. (Chickpea)

Asuman Kan1, Berrin Özçelik2* and Murat Kartal3
1Programme for Food Technologies, Vocational School of Technical Sciences, University of Selçuk, Konya, Turkey. 2Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Gazi University, Ankara, Turkey. 3Department of Pharmacognosy, Faculty of Pharmacy, University of Ankara, Ankara, Turkey.
Email: [email protected], [email protected]

  •  Accepted: 08 November 2009
  •  Published: 31 December 2009

Abstract

The objective of this study was to evaluation antiviral activities of the extracts from the seed, fruit skin and aerial parts of ten registered varieties Cicer arietinum (Chickpea) against Herpes simplex type 1 (HSV-1) and Parainfluenza-3 (PI-3) viruses. Madin-Darby Bovine Kidney and Vero cell lines were employed for antiviral assessment of the Citer arientinum L. extracts, in which acyclovir for HSV-1 and oseltamivir for PI-3 were tested as reference drugs. This is the first report showing that C. arietinum seed extracts of Cse-5 possesses significant antiviral activity both of DNA (32 - 4 µg ml-1) and RNA (32 - 16 µg ml-1) viruses compared to the fruit skin and aerial part extracts as well as the controls.  Besides, the extracts of fruit skin (Cfs-4) and aerial parts (Cap-5) showed remarkable activity against DNA viruses at 32 - 1 µg ml-1.

 

Key words: Antibacterial, antifungal, antiviral activity, Cicer arietinum, chickpea.