African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2183

Full Length Research Paper

Evaluation of curcumin toxicity in rats through biochemical and hematological parameters

Ketllyn S. Voncik
  • Ketllyn S. Voncik
  • Health Sciences Sector, Graduate Program in Pharmaceutical Sciences. Midwestern State University (UNICENTRO), Guarapuava-PR, Brazil.
  • Google Scholar
Raissa H. de Mattos
  • Raissa H. de Mattos
  • Health Sciences Sector, Department of Pharmacy. Midwestern State University (UNICENTRO), Guarapuava-PR, Brazil.
  • Google Scholar
Weber C. F. N. da Silva
  • Weber C. F. N. da Silva
  • Health Sciences Sector, Department of Pharmacy. Midwestern State University (UNICENTRO), Guarapuava-PR, Brazil.
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Guilherme B. L. de Freitas
  • Guilherme B. L. de Freitas
  • Graduate Program in Internal Medicine and Health Sciences, Federal University of Parana (UFPR), Curitiba-PR, Brazil.
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Timothy G. Cavazzatto
  • Timothy G. Cavazzatto
  • Master Degree Student in the Graduate Program in Physical Education EMU-UEL. Londrina State University. Highway Celso Garcia, Mile 380, University Campus, Londrina-PR, CEP: 86057-970, Brazil.
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Joao B. T. da Rocha
  • Joao B. T. da Rocha
  • Federal University of Santa Maria (UFMS), Center of Natural and Exact Sciences, Department of Chemistry, Avenue Roraima, 1000 - University Town, Zip Code: 97105-900 Bairro Camobi - Santa Maria ? RS, Brazil.
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Najeh M. Khalil
  • Najeh M. Khalil
  • Health Sciences Sector, Department of Pharmacy. Midwestern State University (UNICENTRO), Guarapuava-PR, Brazil.
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Juliana S. Bonini*
  • Juliana S. Bonini*
  • Health Sciences Sector, Department of Pharmacy. Midwestern State University (UNICENTRO), Guarapuava-PR, Brazil.
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  •  Received: 16 May 2015
  •  Accepted: 01 July 2015
  •  Published: 08 August 2015

Abstract

Curcumin is a natural compound known for hepatic and nephroprotective actions, however, there is little research related to its possible side effects. The research aimed to study hematological, biochemical parameters and histopathology of hepatic and renal tissues to evaluate the effects of curcumin toxicity in male rats. A group of Wistar male rats (n = 10) was orally treated for five days with 100 mg/kg of curcumin diluted in vegetable oil, and the other group (n=10) was treated with vegetable oil (control). Statistical difference was observed in the levels of creatinine, hematocrit, hemoglobin, and red blood cells count between the control and curcumin treated group. However, despite these differences, the values observed were within the normal ranges for of Wistar male rats. Histopathological alterations were not observed. Therefore, our results show that curcumin is relatively non-toxic and, because of its demonstrated pharmacological effects, it can be developed as a promising candidate drug.

Key words: Curcumin, toxicity, side effects.