African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Nutritional investigation and biological activities of Parthenium hysterophorus

Rahmat Ali Khan1*, Mushtaq Ahmed1, Muhammad Rashid Khan2, Muhammad Yasir3, Bakhtiar Muhammad3 and Rashid Khan3
1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu KPK, Pakistan. 2Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, Pakistan. 3Department of Chemistry, Hazara University, Mahsehra, Pakistan.
Email: [email protected]

  •  Accepted: 30 September 2011
  •  Published: 15 November 2011


Parthenium hysterophorus is used as a vegetable and in the treatment of various human ailments traditionally in Pakistan. The current study was arranged to investigate the nutritional importance, microbial inhibition and its potency against free radicals. The results revealed that extract possesses macro elements Ca, K, Na, Mg, Fe, Zn, as well as micro elements including Ni, Li, Pb, Co, Mn, Cu, Cr, and Cd. Scavenging of free radicals revealed that methanolic extract of P. hysterophorus (PM) possesses lowest IC50 (2.5 ± 0.05 μg/ml) comparatively to ascorbic acid (3.7 ± 0.03) and n-hexane extract of P. hysterophorus (PH) (5.1 ± 0.07 μg/ml). The extracts also showed maximum antibacterial potential in various concentrations of n-hexane and methanolic extract of P. hysterophorus. The results revealed that P. hysterophorus contain a remarkable fungal inhibition due to the presence of bioactive constituents. Based on this screening various fractions of P. hysterophorus are recommended for future bioassay guided isolation of bioactive constituents.


Key words: Parthenium hysterophorus, nutritional analysis, antimicrobial activity, 1,1-diphenyl 1-2-picryl-hydrazyl (DPPH).