African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 15 November, 2011; 5(18)

November 2011

Toxicology of baytril (enrofloxacin)

The prophylactic use of drugs, chemicals and biological substances are necessary to meet the sanitation standards used to maintain high levels of health status. The aim of this article was to present the basic data of the active substance of enrofloxacin, the pharmacokinetics, pharmacodynamics and also the pharmacological safety of this drug. Enrofloxacin as a molecule belongs to the quinolone antimicrobial family, and...

Author(s): Ebrahim Babaahmady and Afra Khosravi

November 2011

Clinical analysis of nodular ground- glass opacity appearance of lung cancer on computerized tomography (CT)

The aim of the study is to investigate the diagnosis and treatment of patients who had appearance of nodular ground- glass opacity (NGGO) on computerized tomographic (CT). We retrospectively analyzed 14 cases who appeared NGGO on thin section CT:  Male 5, female 9, aged from 31 to 76 years, average 56.3 years old; NGGO diameter was 1.0 to 3.0 cm, average 2.1 cm. Among all the cases, 12 patients have solid parts in...

Author(s): Xiandong Tao, Xuewei Zhao, Tiewen Pan and Jiang Hong

November 2011

Role of heat shock protein in renal ischemic reperfusion injury in rats

The current study was designed to address the question of whether inducing heat shock proteins (HSPs) by herbimycin A might have a renoprotective effect in ischemic reperfusion (I/R) injury to rat kidney. The study was conducted on 56 male Wistar albino rats that were divided into three groups: Group I was subdivided into group Ia in which sham operation was done, Group Ib in which sham operation was done also received...

Author(s): A. Baraka and M. Ghoneim

November 2011

Antibacterial effect of Euphorbia supina extracts against methicillin-resistant Staphylococcus aureus under dark and light intensity

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious clinical urgent problem worldwide. Few new drugs are available against methicillin-resistant S. aureus (MRSA), because MRSA has the ability to acquire resistance to most antibiotics, which consequently increases the cost of medication. In the present study, the antibacterial activity of Euphorbia supina has been investigated....

Author(s): Dae-Ki Joung, Young-Hwa Kim, Hee-Joung, Da-wun Yang , Dong-Yeul Kwon, Jang-Gi Choi, Seo-Woo, Dong-Young Shin, Oh-Hyun Kweon, Kee-Tae Kweon and Dong-Won Shin

November 2011

Prophylactic use of antibiotics for clean operative procedures

To present the current situation of prophylactic use of antibiotics for clean operative procedures in the department of surgery of our hospital, a total of 2000 cases with clean operative procedures were randomly selected from January 2011 to June 2011 and reviewed. Results showed all patients received prophylactic use of antibiotics (100%), which was performed at 0.5 to 2 h before surgery in 1204 cases (60.2%), at...

Author(s): Lidao Bao, Xianhua Ren , Yi Wang and Nan Wang

November 2011

Phytochemical constituents and antioxidant potential of some underused fruits

Phenols, a major group of antioxidant phytochemicals, have profound importance due to their biological and free radical scavenging activities. To identify their potential sources, extracts of some underused fruits (Muntingia calabura, Averrhoea bilimbi and Artocarpus altilis) were assessed with regard to their total phenolics and flavonoid content, as well as antioxidant activity in different solvent...

Author(s): Firdose R. Kolar, Vaishali S. Kamble and Ghansham B. Dixit

November 2011

Nutritional investigation and biological activities of Parthenium hysterophorus

Parthenium hysterophorus is used as a vegetable and in the treatment of various human ailments traditionally in Pakistan. The current study was arranged to investigate the nutritional importance, microbial inhibition and its potency against free radicals. The results revealed that extract possesses macro elements Ca, K, Na, Mg, Fe, Zn, as well as micro elements including Ni, Li, Pb, Co, Mn, Cu, Cr, and Cd....

Author(s): Rahmat Ali Khan, Mushtaq Ahmed, Muhammad Rashid Khan, Muhammad Yasir, Bakhtiar Muhammad and Rashid Khan

November 2011

In vitro and in vivo studies of antioxidant activities of flavonoids from Adiantum capillus-veneris L.

In this study, ultrasonic-assisted extraction was used to extract flavonoids from Adiantum capillus-veneris L. The crude flavonoids of Adiantum (FA) were then purified with the AB-8 macroporous adsorption resin. The antioxidant activities of the purified FA were evaluated and compared with synthetic antioxidants in scavenging capability of 1, 1-diphenyl 1-2-picryl-hydrazyl (DPPH) free radical, scavenging capacity...

Author(s): Ming-Zhu Jiang, Hui Yan, Yan Wen and Xiang-Mei Li

November 2011

Synthesis and in vitro nematicidal activity of new chalcones vectorised by imidazopyridine

A series of 3-(3-Arylpropenoyl)imidazopyridine (5a to z) was synthesized by crotonization reaction of 2-methyl-3-acetylimidazopyridine with arylaldehyde derivatives. Structuraldetermination of these new chalcones was done by 1H nuclear magnetic resonance (NMR),13C NMR and electrospray ionization (ESI) mass spectroscopy. All compounds have beenevaluated in...

Author(s): Drissa Sissouma, Mahama Ouattara, Mamidou W. Koné, Hervé E. Menan, Ané Adjou and Lassina Ouattara

November 2011

Sildenafil up-regulates Kv1.5 mRNA expression in rats with pulmonary hypertension

The effects of sildenafil on pulmonary vascular remodeling as well as potassium channels (Kv1.5) activity of pulmonary vasculature has not been clearly addressed in pulmonary hypertension secondary to left-to-right shunt. A rat model with pulmonary hypertension secondary to left-to-right shunt was established by performing an abdominal aorta to inferior vena cava fistula. Twenty-seven male Sprague-Dawley (SD) rats...

Author(s): Lei Hu, Lin-hua Tan, Jia-jie Fan, Shan-shan Shi, Li-zhong Du, Long Lin and Qiang Shu

November 2011

Simultaneous determination of ibuprofen and diphenhydramine HCl in orally disintegrating tablets and its dissolution by reversed-phase high performance liquid chromatography (RP-HPLC)

Reversed-phase high performance liquid chromatography (RP-HPLC) methods were established for the simultaneous determination of ibuprofen (IBU) and diphenhydramine HCl (DPH) in orally disintegrating tablets (ODTs) and its dissolution in this work. The separation was performed on a Shim-pack VP-ODS C18 (150 × 4.6 mm, 5 µm) column. The mobile phases of determination and dissolution were a mixture...

Author(s): Z. K. Ge, Y. H. Luo, X. Y. Zhao, Y. J. Zhang, H. Zhang and C. C. Tian

November 2011

Immunological and histological effects of exposure to imidacloprid insecticide in male albino rats

Imidacloprid (IC) is a relatively new systemic insecticide related to the tobacco toxin nicotine. The effects of repeated oral administration of IC over 4 weeks on immune response, oxidative stress and hepatotoxicity were assessed. Forty-eight adult male albino rats were divided into two groups of twenty-four animals each. The control group was orally administered distilled water, while the IC-treated group was orally...

Author(s): Mohamed Mohany, Gamal Badr, Inas Refaat and Mostafa El-Feki

November 2011

Adiponectin: A new therapeutic option for periprosthetic osteolysis

Periprosthetic osteolysis is the most prevalent complication after total joint arthroplasty. It often results in aseptic loosening of the implant, which is required for revision surgery. Wear debris has been recognized as a key factor in the initiation and development of periprosthetic osteolysis, and yet there is no approved treatment available to it. Adiponectin is a hormone secreted by adipose tissue. Many...

Author(s): Juncheng Cui , Zhihong Li, Wanchun Wang and Li Zeng