African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Subchronic toxicity evaluation of the hydroethanolic extract from Endopleura uchi (Huber) Cuatrec in Wistar rats

Beatriz M. Sa
  • Beatriz M. Sa
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
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Clarissa S. Lima
  • Clarissa S. Lima
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
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Uriel Davi A. Silva
  • Uriel Davi A. Silva
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
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Helison O. Carvalho
  • Helison O. Carvalho
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
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Caio P. Fernandes
  • Caio P. Fernandes
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
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Rafael L. Resque
  • Rafael L. Resque
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
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Tania T. de Oliveria
  • Tania T. de Oliveria
  • Laboratorio de Biofarmacos, Departamento de Bioquimica e Biologia Molecar, Universidade Federal de Vicosa, Minas Gerais, Brasil
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Jose Carlos T. Carvalho*
  • Jose Carlos T. Carvalho*
  • Programa de Pos-Graduacao em Biodiversidade Tropical, Universidade Federal do Amapa, Amapa, Brasil.
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  •  Received: 30 October 2014
  •  Accepted: 03 February 2015
  •  Published: 28 February 2015

Abstract

Endopleura uchi (Huber) Cuatrec. (Humiriaceae) is a species from Brazilian Amazon rainforest, popularly used against menstrual disorders and uterine inflammation. This study aimed to evaluate the subchronic toxicity of hydroethanolic extract from E. uchi (EHEEu) in Wistar rats based on biochemical and hematological parameters. Rats were treated with daily doses of EHEEu (500 mg/kg - gavage), and then hematological and biochemical parameters were observed. The results shows that the treatment performed produced no signs of toxicity or death, as well as no changes in weight gain or daily intake of water and food. Biochemical and hematological parameters were not modified by EHEEu administration, with the exception of erythrocyte index of rats (males) in the treated group, however, it was not assigned clinical relevance once it remained within the reference range for the species. Thus, subchronic administration of EHEEu produced no toxic effects in Wistar rats.

Key words: Endopleura uchi, subchronic treatment, hematology, biochemistry.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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