African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Full Length Research Paper

Subchronic toxicity evaluation of the hydroethanolic extract from Endopleura uchi (Huber) Cuatrec in Wistar rats

Beatriz M. Sa
  • Beatriz M. Sa
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
  • Google Scholar
Clarissa S. Lima
  • Clarissa S. Lima
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
  • Google Scholar
Uriel Davi A. Silva
  • Uriel Davi A. Silva
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
  • Google Scholar
Helison O. Carvalho
  • Helison O. Carvalho
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
  • Google Scholar
Caio P. Fernandes
  • Caio P. Fernandes
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
  • Google Scholar
Rafael L. Resque
  • Rafael L. Resque
  • Laboratorio de Pesquisa em Farmacos,Departamento de Ciencias Biologicas e da Saude, Universidade Federal do Amapa, Amapa, Brasil.
  • Google Scholar
Tania T. de Oliveria
  • Tania T. de Oliveria
  • Laboratorio de Biofarmacos, Departamento de Bioquimica e Biologia Molecar, Universidade Federal de Vicosa, Minas Gerais, Brasil
  • Google Scholar
Jose Carlos T. Carvalho*
  • Jose Carlos T. Carvalho*
  • Programa de Pos-Graduacao em Biodiversidade Tropical, Universidade Federal do Amapa, Amapa, Brasil.
  • Google Scholar


  •  Received: 30 October 2014
  •  Accepted: 03 February 2015
  •  Published: 28 February 2015

Abstract

Endopleura uchi (Huber) Cuatrec. (Humiriaceae) is a species from Brazilian Amazon rainforest, popularly used against menstrual disorders and uterine inflammation. This study aimed to evaluate the subchronic toxicity of hydroethanolic extract from E. uchi (EHEEu) in Wistar rats based on biochemical and hematological parameters. Rats were treated with daily doses of EHEEu (500 mg/kg - gavage), and then hematological and biochemical parameters were observed. The results shows that the treatment performed produced no signs of toxicity or death, as well as no changes in weight gain or daily intake of water and food. Biochemical and hematological parameters were not modified by EHEEu administration, with the exception of erythrocyte index of rats (males) in the treated group, however, it was not assigned clinical relevance once it remained within the reference range for the species. Thus, subchronic administration of EHEEu produced no toxic effects in Wistar rats.

Key words: Endopleura uchi, subchronic treatment, hematology, biochemistry.