Abstract

This study aims to investigate the effects of Nigella sativa seeds (NSS) on fertility of male diabetic rats. Animals were divided into 3 groups, one group was kept as control and the two other were rendered diabetic by alloxan (120 mg/kg b.wt). One group was left as diabetic control (Diab) and the second were treated (Diab+N) with 2% of NSS in diet for 30 days. Blood samples were collected for glucose and testosterone levels. Testis, epididymis, prostates and seminal vesicles were removed for sperm parameters and oxidant/antioxidant status. NSS improve semen quantity and mobility, and testosterone levels and testis; they decrease blood glucose and lipid peroxidation product level (LPO) and improve antioxidant activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), and aspartate and alanine aminotransferase (AST and ALT). NNS as a diet may be beneficial for diabetic fertility.

Key words: Diabetes, Nigella sativa seeds, oxidative stress, reproductive system.