African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2250

Comparing the effect of vitamin B1 (vit. B1) and ibuberofen on the treatment of primary dysmenorhea

Mandana Zafari*, Aghamohammady A. and Tofighi M.
Department of midwifery, Islamic Azad University, Sari Branch, Sari, Iran.
Email: [email protected]

  •  Accepted: 08 June 2011
  •  Published: 31 July 2011


Primary dysmenorhea refers to painful contractions of menses which are without organic complications and its incidence is about 80%. The purpose of this study is to compare the effect of vitamin B1 (vit. B1) and ibuberofen on the treatment of primary dysmenorhea. This clinical trial study was done on medicine students of Islamic Azad University, Sari branch, in 2010. One hundred and fifty-two students that had moderate and severe dysmenorhea were sited in two groups randomly. The first group (76 girls) received 100 mg/day vit. B1 in the luteal phase and the second group received 400 mg ibuberofen when their pain started (duration of this study was 2 months). After data collection, data analysis was done by SPSS version software and we used chi-square tests, t-test, Mann-Whitney and Freidman tests (α = 0.05). There was significant difference between intensity and duration of pain before and after treatment by ibuberofen (p = 0.000) and vit. B1 (p = 0.000). Furthermore, there was no difference between the intensity of pain after intervention in the two groups in the first month (p = 0.414), but there was difference in the second (p = 0.000) and third (p = 0.000) months. Also, there was no difference between the two groups about needing more drugs to reduce the pain (p = 0.401). The effect of vit. B1 and ibuberofen are similar, but vit. B1 has less complications and it is more accepted and used in treatment of primary dysmenorhea.


Key words: Primary dysmenorhea, Ibuberofen, vitamin B1 (vit. B1).