African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: July 2011; 5(7)

July 2011

Preparation and characterization of crosslinked and non-crosslinked polycaprolactone fumarate (PCLF) NPs as carriers for doxorubicin HCl

Polycaprolactone fumarate (PCLF) is a biocompatible and biodegradable polyester which has been evaluated for tissue engineering. Hydrophobic PCLF nanoparticles (NPs) may be uptaken by reticule endotelial system rich organs and useful for treatment of related tumors. NPs of three PCLFs were produced through nanoprecipitation method. Crosslinked (CR) NPs were prepared using Benzyl peroxide (BPO) and N-vinyl...

Author(s): Narges Shokri, Hamid Akbari Javar, Shamileh Fouladdel, Ali Khalaj, Rasoul Dinarvand, and Ebrahim Azizi 

July 2011

Acute toxicity and anti-inflammatory activity of aqueous ethanol extract of root bark of Ximenia americana L. (Olacaceae)

Ximenia americana L. (Olacaceae) is a folk medicinal plant used in Burkina Faso to treat inflammatory, noxious and infectious diseases. The aim of this study was to evaluate anti-inflammatory properties of aqueous ethanol extract of root bark of the plant and evaluate its acute toxicity. Carrageenan was used to induce oedema and leukocyte migration; acetic acid was used to induce vascular permeability in order to...

Author(s): Onifade Al-fattah Olabissi, Ouedraogo Moussa, Ouedraogo Moustapha, Zongo Frank Edgard, Kafando Eléonore, Lompo Marius and Guissou Innocent Pierre,

July 2011

Assessment of drug interactions in elderly patients of a family health care unit in Aracaju (Brazil): A pilot study

This pilot study aimed to assess drug-drug and drug-food interactions in elderly patients of a Family Health Care Unit in Aracaju, Brazil. A descriptive pilot study was performed through an interview questionnaire with 35 elderly patients (28 women) of the Family Health Care Unit. The range of consumed medications was 1 to 7, and the rate was 3.1 medications/person. This pilot study identified that 34 elderly used...

Author(s): Raquel S. Mendes-Netto, Claudia Q. V. Silva, Alfredo D. Oliveira Filho, Chiara E. Rocha and Divaldo P. Lyra-Junior

July 2011

Clinical and radiological results of posterior instrumentation without fusion for thoracolumbar fractures

A retrospective study of clinical and radiological results of nonfusion operative treatment for thoracolumbar fractures. In this study, we aimed to demonstrate that fusion was not always required in the surgical treatment with posterior instrumentation for thoracolumbar vertebral fractures and to show the success of surgical treatment without fusion. Fusion was added considering failure of the implant and inability to...

Author(s): Serdar Sargın, Bekir Yavuz Uçar, Serdar Necmioğlu, Mehmet Bulut and Mehmet Gem  

July 2011

Anticarcinogenic activity of Labisia pumila against 7, 12- dimethylbenz (a) anthracene (DMBA)/croton oil-induced mouse skin carcinogenesis

Labisia pumila or locally known as Kacip Fatimah, is one of the most popular medicinal herb in Malaysia. Anticarcinogenic activity of this medicinal herb however, has not been reported until today. In this paper, the in vivo anticarcinogenic activity of L. pumilaethanol extract on two-stage mouse skin carcinogenesis model is reported. In the present study, we investigated whether L....

Author(s): Azimahtol Hawariah Lope Pihie, Fezah Othman, and Zainul Amiruddin Zakaria

July 2011

Vasomotor effect of cyclovirobuxine D and its underlying mechanisms

To investigate the vasomotor effects of Cyclovirobuxine D (CVB) on the rat aortic ringsin vitro and underlying mechanisms, rat aorta was obtained, and aortic rings with or without endothelium were pre-treated with potassium chloride (KCl) or phenylephrine (PE). Then, CVB was added and its vasomotor effects were observed. In addition, the influence of other drugs on the CVB induced vasomotor effects was detected....

Author(s): Xinhua Zhang, Yongmei Han, Biqi Zhang and Shenjiang Hu

July 2011

Antioxidant properties of crude and fractionated extracts of Alpinia mutica rhizomes and their total phenolic content

In the present study, the antioxidant potential of the crude methanol and its fractionated extracts (hexane, ethyl acetate and water) of the rhizomes of Alpinia mutica was investigated, employing four different assays. The antioxidant assays used were 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, b-carotene bleaching,superoxide dismutase (SOD) and the reducing power assays while the total...

Author(s): Chung-Weng Phang, Sri Nurestri Abd Malek, Halijah Ibrahim and Norhanom Abdul Wahab

July 2011

Modification of oxidative stress in acute exhaustive exercise mice with n-butanol and water fractions from Pedicularis decora Franch root treatment

The current study investigated the effect of n-butanol and water fractions of Pedicularis decora Franch on oxidative stress induced by an acute exhaustive exercise. Institute of Cancer Research (ICR) mice were divided into sedentary, exercise and recovery groups. Each group includes control and water fraction as well as n-butanol fraction subgroup. Mice were treated with the two fractions of P....

Author(s): Meili Gao, Yili Wang, Lijuan Wang, Yongfei Li and Jianxiong Yang

July 2011

Physicochemical characterization and in-vitro evaluation of flubiprofen oral controlled release matrix tablets: Role of ether derivative polymer ethocel

The main aim of the study was to develop once-daily controlled release matrix tablet of the selected propionic acid derivative flubiprofen (100 mg) using ethyl cellulose ether derivative release controlling polymer. Preformulation factors, including solubility, powder flowability and compressibility, and loss on drying were studied. Hausner’s factor and angle of repose ranged from 1.10 to 1.25 and 25 to 29°...

Author(s): Muhammad Akhlaq, Gul Majid Khan, Abdul Wahab, Hamdy Abdelkader, Raid Alany Abid Hussain and Nauman Rahim Khan

July 2011

Comparing the effect of vitamin B1 (vit. B1) and ibuberofen on the treatment of primary dysmenorhea

Primary dysmenorhea refers to painful contractions of menses which are without organic complications and its incidence is about 80%. The purpose of this study is to compare the effect of vitamin B1 (vit. B1) and ibuberofen on the treatment of primary dysmenorhea. This clinical trial study was done on medicine students of Islamic Azad University, Sari branch, in 2010. One hundred and fifty-two students that had moderate...

Author(s): Mandana Zafari, Aghamohammady A. and Tofighi M.

July 2011

Effect of the matrices and penetration enhancers in elemene transdermal drug delivery system

The objective of this study is to develop an elemene transdermal drug delivery system by choosing suitable drug-loaded matrices and permeation enhancers and to observe their effects in this system. The in vitro transdermal release profiles were determined by Franz diffusion cells. The content of elemene in the collected samples was determined by gas chromatograph. Polyvinyl alcohol and sodium carboxymethyl...

Author(s): Zhaowu Zeng, ,Jing Lin, Haifeng Li, Tian Xi, Wei Zhou, Haizhu Fan, Xiaori Zhan, Shuling Wang, Anming Wang, Xiaoli Wang and Xingyan Liu

July 2011

Antibacterial activity analysis of extracts of various plants against gram -positive and -negative bacteria

The methanolic, hot water and cold water extracts of Pistacia Integerrima (gall),Polygonum Bistorta (root), Swetia Charita (stem) and Zingiber officinale (root) were screened against gram positive bacteria like Bacillus subtilis (ATCC 6633),Entereococcus faecalis (ATCC 14506) and Staphylococcus aureus (ATCC 6538), and gram negative bacteria...

Author(s): Anwar Khalid, Amir Waseem, Malik Saadullah, Uzair-Ur-Rehman, Sonia Khiljee, Ayesha Sethi, Muhammad Hassham Hassan Bin Asad, Fatima Rasool, Muhammad Khurram Waqas and Ghulam Murtaza

July 2011

Apoptotic and necrotic effects of carboxylated quercetin/polyethylenimine complex on HeLa cells

The effects of quercetin (Q), carboxylated quercetin (CQ) and carboxylated quercetin/polyethylenimine (CQ/PEI) complex on HeLa cell cultures were investigated. Firstly, carboxylated quercetin was acquired through hydroxyl groups of quercetin, using chloroacetic acid. The complex of CQ/PEI was acquired by electron cooperation path over polietilenimine amine groups and quercetin carboxyl groups. CQ and...

Author(s): Murat Uluğ, Mustafa Türk, Serpil Oğuztüzün, Yusuf Menemen and Gülten Kahraman

July 2011

Recovery of spermatogenesis by Allium cepa in Toxoplasma gondii infected rats

Toxoplasma gondii is a protozoan parasite that is globally widespread and infects man and animals; we investigated effect of Allium cepa on sperm parameters, testestrone level in male rats experimentally infected by toxoplasma. Wistar male rats (n=40) were allocated into four groups, control group (n=10) and T1 group that received tachyzoites of T. gondii (IP) (n=10), and T2 group that...

Author(s): Arash Khaki, Laya Farzadi, Shahin Ahmadi, Elham Ghadamkheir, Amir afshin Khaki, Saedeh shojaee and Reza Sahizadeh

July 2011

Effect of atorvastatin on aldosterone induced myocardial fibrosis in a rat model and its potential mechanism

In this study, we investigated the effects of atorvastatin on aldosterone induced myocardial fibrosis in rat model and its potential mechanism. Forty male rats underwent right nephrectomy, and then, were given free access to 1% NaCl for 4 weeks. During this period, rats were randomly divided into 4 groups; vehicle group (CON group: Subcutaneous injection of saline); aldosterone treated group (ALD group: Aldosterone 18...

Author(s): Li-kun Ma, Li-feng He, Bing-yu Zhang and Jing-sheng Hua

July 2011

A fast and simple HPLC-UV method for simultaneous determination of three anti-cancer agents in plasma of breast cancer patients and its application to clinical pharmacokinetics

A rapid, sensitive and reproducible high performance liquid chromatographic (HPLC) method was developed and validated in plasma for simultaneous quantification of 5-fluorouracil, adriamycin and cyclophosphamide (FAC) which are being prescribed in cancer chemotherapy. Isocratic RP-HPLC system (Agilent technologies USA) with C18column (4.6 mm × 250 mm i.d., 5 µ particle size) and a detector UV-VWD was...

Author(s): Mahmood Ahmad, Muhammad Usman, Asadullah Madni, M. Zubair, Qamar-uz-Zaman, M. Saleem Qureshi, Abubakar Munir, Mahtab Ahmad and Arshad Mahmood

July 2011

Effects of chronic lead acetate exposure on bone marrow lipid peroxidation and antioxidant enzyme activities in rats

Occupational and environmental exposure of lead (Pb) is a serious health problem in developing and industrialized countries around the world. Toxic effect of lead is closely related to its accumulation in important tissues after its absorption into the blood. Present study looked into the effect of lead toxicity on bone marrow oxidative biomarkers in Sprague-Dawley rats. Rats were divided into four groups and in three...

Author(s): Nagaraja Haleagrahara, Srikumar Chakravarthi, Anupama Bangra Kulur and Ammu Radhakrishnan

July 2011

Modeling of nevirapine-based antiretroviral regimen response by taxonomy from different CD4 cell counts strata

The search for determinants responsible for changes in CD4 cells count can help to optimize the efficiency of the nevirapine-based antiretroviral therapy in Côte d'Ivoire. Our study on the response to this treatment was carried out through taxonomy of CD4 cells count trajectories using non-hierarchical-descendant model. One hundred and sixty four patients were grouped according to their baseline CD4 count in...

Author(s): Danho Pascal Abrogoua, Brou Jérôme Kablan, Gilles Aulagner and Claude Petit

July 2011

Effect of Berberis aristata on lipid profile and coagulation parameters

Herbs have been a great source of natural substances used to treat and prevent several cardiovascular diseases such as hypertension, atherosclerosis, angina pectoris, arrhythmia etc. Blood lipid levels and coagulation parameters are probably the major determinant of the development of cardiovascular diseases, hence the present study has been specifically designed to investigate the effect of Berberis...

Author(s): Faiza Abdul Razzaq, Rafeeq Alam Khan, Zeeshan Feroz, and Syeda Afroz

July 2011

Syzygium cumini (pomposia) active principles exhibit potent anticancer and antioxidant activities

The antioxidant and anticancer activities of Syzygium cumini fruit extracts were investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging assay and viability of leukemia cancer cells (AML cell line) respectively. The successive extracts, hexane, chloroform, ether, ethyl acetate, ethanol and water were prepared and subjected to antioxidant and anticancer evaluation. The results showed...

Author(s): Abd El-Moneim M. R. Afify, Sayed A. Fayed, Emad A. Shalaby and Hany A. El-Shemy,

July 2011

Antioxidant and anti-proliferative activities of Roselle juice on Caov-3, MCF-7, MDA-MB-231 and HeLa cancer cell lines

Roselle (Hibiscus sabdariffa Linn) extract has been scientifically proven to possess high antioxidant activity, anti-proliferation and anti-carcinogenic properties. This study was conducted to evaluate the antioxidative capacity of commercialized Roselle juice (RJ) at three storage periods and its anti-proliferative effect on breast (MCF-7 and MDA-MB-231), ovarian (Caov-3) and cervical (HeLa) cancer cell lines. The...

Author(s): Abdah Md Akim, Lim Chooi Ling, Asmah Rahmat and Zainul Amiruddin Zakaria

July 2011

Antioxidant activities and RP-HPLC identification of polyphenols in the acetone 80 extract of Salvadora persica

Salvadora persica L. is one of the oldest known oral hygiene tools with high therapeutic effects on cariogenic bacteria and periodontal pathogens due to its well documented chemical constituents. In this paper, and for the first time, we report the use of RP-HPLC technique to identify the polyphenols in the acetone 80 extract obtained from stems of S. persica. The antioxidant properties (total...

Author(s): Emira Noumi, Hafedh Hajlaoui, Najla Trabelsi, Riadh Ksouri, Amina Bakhrouf and Mejdi Snoussi,

July 2011

Prevalence of self-medication and health-seeking behavior in a developing country

A randomized, cross-sectional, multi-center study in five cities of Pakistan was under taken amongst a sample of randomly selected urban and rural household to ascertain the health seeking behavior and self-medication by members of the community. Modern drugs were available in 64.2% of households, other drugs, 32.7% had no drugs and 4.1% no drugs. The common drugs available in the homes of urban areas were 66%...

Author(s): Shahzad Hussain, Farnaz Malik, Kazi Muhammad Ashfaq, Ghazala Parveen, Abdul Hameed, Safia Ahmad, Humayun Riaz, Pervaiz Akhtar Shah and Tarik Saeed

July 2011

Leptin decreases the sensitivity of human colon cancer cell HT-29 to 5-flurouracil

Toxoplasma gondii is a protozoan parasite that is globally widespread and infects man and animals; we investigated effect of Allium cepa on sperm parameters, testestrone level in male rats experimentally infected by toxoplasma. Wistar male rats (n=40) were allocated into four groups, control group (n=10) and T1 group that received tachyzoites of T. gondii (IP) (n=10), and T2 group that...

Author(s): Lei Shen, He-sheng Luo, Jun Sun, and Liang Zhao,

July 2011

Antitumor effects of cucurmosin in human chronic myeloid leukemia occur through cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis

Cucurmosin, a novel type 1 ribosome-inactivating protein, induced cell death in various cell types including several tumor cell lines. However, the mechanism remained largely uncharacterized. In this study, we investigated the possible mechanism underlying its cytotoxicity by using K562 cells. In the study, typical characteristics of apoptosis, such as cell shrinkage, apoptotic bodies, cell cycle arrest and DNA...

Author(s): Jieming Xie#, Wenzhong Que#, Minghuang Chen, Jiancheng Sun, Tinbo Liu, Huili Liu, Mei Liu, Aiqin Yang, Pei Yang and Yulu Wang