Abstract

The aim of the present study was to investigate the influence of chloroquine on some vital tissues of mice (gastrocnemius muscle and spleen). Healthy adult male Swiss albino mice weighing between 30 and 40 g were used for the study. Treated group was exposed to 200 mg/kg body weight/day of chloroquine phosphate given orally for 45 days. Control animals were given distilled water for the same period. Microscopic examination of muscle and spleen revealed concomitant changes in histology. Thus, the use of chloroquine for longer periods requires strict monitoring as chronic usage may lead to many detrimental effects in the host.

Key words: Malaria, Chloroquine, toxicity, gastrocnemius muscle, spleen.