March 2013
Role of cyclin-dependent kinase 5 in neurodegenerative disorders
Alzheimer’s disease (AD) is a neurodegenerative confusion associated with dementia. AD is indicated by progressive loss of memory. It is having characteristic evidence of β-amyloid extracellularly and neurofibrillary tangle’s development intracellularly. Neurons lose the capability of cell division after they attain full development. Cyclin dependent kinase 5 (Cdk5) is a kinase protein which is...
March 2013
Pharmacokinetic/Pharmacodynamic (PK/PD) modeling of antipyretic effect of meloxicam: A preferential cyclooxygenase inhibitor in rat
The main purpose of this study was to predict the efficacy, potency and sensitivity of meloxicam (a preferential cyclooxygenase-2 (COX-2) inhibitor) antipyretic effect by using a simple indirect response model in rat, evaluated by Brewer’s yeast induced model. The rats received 1, 3, 7 and 10 mg/kg of meloxicam, after subcutaneous (sc) injection of Brewer’s yeast. The plasma concentrations of...
March 2013
Proteomic analysis of the diagnostic biomarker for childhood infectious mononucleosis
To investigate the different expressions of protein spectra in sera from children with infectious mononucleosis (IM) at acute stage and recovery stage in order to screen out potential protein biomarkers for children IM, the fingerprints of serum protein were obtained from the healthy (controls), acute upper respiratory infection (AURI), acute IM and recovery IM children using surface enhanced laser desorption/ionization...
March 2013
Homocysteine, not high-sensitivity C-reactive protein, associates with the intima-media thickness of carotid artery and arterial stiffness
The study objective was to assess the relationship between carotid intima-media thickness (IMT) and arterial stiffness in subjects with hypertension, and to investigate the risk factors for increasing carotid IMT and arterial stiffening. 336 eligible residents participated in a community-based survey. Arterial stiffness and carotid intima-media thickness (IMT) were evaluated using carotid arterial stiffness parameter...
March 2013
Some pharmacological actions of Myrica rubra part 1: Effect on experimentally-induced gastric ulcers, inflammation and haemorrhoids in rats
Chinese arbutus (Myrica rubra) fruits or Yumberry, are stony red fruits with berry-like edible portions growing in China, India, Japan and some other south eastern Asian countries. A 50% juice under the trade name Yumberry is available in some countries. It is rich in polyphenols and proanthocyanidins. This study investigated the effect of 4 weeks administration of the juice as a substitute for the normal rats'...
March 2013
Pharmacological activities evaluation of some new pyrazolo-pyrimidino-pyridazine derivatives
Pyrazolo-pyrimidino-pyridazine derivatives are potent compounds with pharmacological activities like anti-inflammatory, analgesic and anti-microbial. Pharmacological screenings proved that the compounds 1 to 6 had high activities comparable with reference drugs. Anti-inflammatory evaluation of the tested compounds comparable with Indomethacin showed that edema inhibition increased with time. All the tested compounds had...
March 2013
Studies on chronic administration of chloroquine on gastrocnemius muscle and spleen of Swiss albino mice
The aim of the present study was to investigate the influence of chloroquine on some vital tissues of mice (gastrocnemius muscle and spleen). Healthy adult male Swiss albino mice weighing between 30 and 40 g were used for the study. Treated group was exposed to 200 mg/kg body weight/day of chloroquine phosphate given orally for 45 days. Control animals were given distilled water for the same period. Microscopic...
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