African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2126

Full Length Research Paper

Effects of aqueous leaf extract of Ocimum gratissimum on oral glucose tolerance test in type-2 model diabetic rats

NELSON I. OGUANOBI*, CHIOLI P. CHIJIOKE and SAMUEL I. GHASI
Clinical Pharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University Of Nigeria, Nsukka, Enugu Campus, Nigeria.
Email: [email protected]

  •  Accepted: 01 February 2012
  •  Published: 08 March 2012

Abstract

Preliminary studies have reported hypoglycaemic effects of leaf extracts of Ocimum gratissimum in type-1 diabetic animal models. However, the mechanism of its antihyperglycaemic activity remains unknown. To shed more light on this activity, we decided to investigate the efficacy of the extract in type-2 model diabetic rats, for which few reliable data are currently available. The results from this study show that aqueous extract of O. gratissimum leaf can significantly reduce postprandial hyperglycaemia in type-2 diabetic model rats, but without the risk of hypoglycemia. This property makes it potentially useful in type-2 diabetes human subjects with insulin resistance who are prone to high postprandial glucose surge.

 

Key words: Streptozotocin, hyperglycaemia, neonatal rat, type-2 diabetes, Ocimum gratissimum.