African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 8 March, 2012; 6(9)

March 2012

Crystallization and transformation of pharmaceutical solid forms

In the past decades, a great progress has been made in the discovery, identification and control of various solid forms of active pharmaceutical ingredients (APIs), including polymorphs, solvates, hydrates, co-crystals, salts and amorphous solids. It is expected that new solid forms with novel properties of pharmaceutical molecules will explosively expand with further understanding of the formation mechanisms of...

Author(s): Jie Lu

March 2012

Anti-cancer activities of α- and γ-tocotrienol against the human lung cancer

Lung cancer is the leading cause of cancer deaths in the world. To find a natural product that can be used in chemoprevention of lung cancer are the promising strategy for cancer prevention and therapy. In this study, we explore the contents of α-tocotrienol and γ-tocotrienol, a subgroup of vitamin E, in Thai rice and investigate their mechanisms underlying their anti-cancer activities on the human alveolar...

Author(s): Suphot Phutthaphadoong, Supachai Yodkeeree, Chaiyavat Chaiyasut and Pornngarm Limtrakul

March 2012

Sources and possible mechanisms of action of important phytoconstituents with cardiovascular properties

Herbal medicines are being centrally focused since ages for the screening of newer and better treatment of health problems especially cardiac diseases. In the current manuscript, we have reviewed a number of important constituents of different herbs and plants, which belong to a wide range of families that affect the cardiovascular system by acting through one mechanism or the other as Rauwolfia serpentine, Nigella...

Author(s): Rabia Altaf, Mohammad Zaini Asmawi, Aidiahmad Dewa and Muhammad Ihtisham Umar

March 2012

In vitro cytotoxic screening of 300 selected Chinese medicinal herbs against human gastric adenocarcinoma SGC-7901 cells

Natural products have traditionally provided a rich source of drugs for many diseases, including cancer, and plants are an important source of novel natural products. Only a fraction of the diversity of the biosphere has been tested for biological activity and novel cancer therapeutics remains to be discovered. The present study was undertaken to evaluate the cytotoxic activity of the crude ethanolic extracts of 300...

Author(s): Azhar Rasul, and Tonghui Ma,

March 2012

Release pattern of three new polymers in Ketoprofen controlled-release tablets

The objective of the study was to formulate and evaluate sustained release polymeric tablets of ketoprofen for the release rate, release patterns and the mechanism involved in the release process of the drug. Formulations with three different types of newly synthesized polymers and one grade of ethyl cellulose ether derivatives (FP100 premium) in several drug-to-polymer ratios (D:P ratio 10:1, 10:2 and 10:3) were...

Author(s): Syed Umer Jan, Gul Majid Khan, Haroon Khan, Asim-ur-Rehman, Kamran Ahmad Khan, Shefaat Ullah Shah, Kifayat Ullah Shah, Amir Badshah and Izhar Hussain

March 2012

Medication adherence of psychiatric patients in an outpatient setting

The success of medication treatment is dependent on a patient’s adherence to the medication regimen and non-adherence amongst psychiatric patients is associated with poor clinical outcomes and high resource utilization. The aim of this study was to assess the levels of medication adherence in psychiatric outpatients and explore factors that influence adherence. Adult, psychiatric outpatients were assessed to (1)...

Author(s): Sanele Mahaye, Thandinceba Mayime, Siyabonga Nkosi, Farzana Noor Mahomed, Londeka Ntuli, Justine Pramlal, Olivia Setlhabana and Frasia Oosthuizen

March 2012

Phyto-chemical analysis, anti-allergic and anti-inflammatory activity of Mentha arvensis in animals

Allergic diseases are fairly common in all parts of the world and involve all ethnic groups with bronchial asthma, allergic rhinitis, conjunctivitis and eczema being the commonest manifestations. Despite our efforts, their incidence is on an escalating path. The use of herbal remedies and standardized extracts for treatment of allergy and other diseases has been gaining momentum in recent years. The qualitative and...

Author(s): Farnaz Malik, Shahzad Hussain, Alia Sadiq, Ghazala Parveen, Amina Wajid, Shazia Shafat, Rafique Ahmad Channa, Rashid Mahmood, Humayun Riaz, Muhammad Ismail and Fahadiya Yasin Raja

March 2012

Effects of aqueous leaf extract of Ocimum gratissimum on oral glucose tolerance test in type-2 model diabetic rats

Preliminary studies have reported hypoglycaemic effects of leaf extracts of Ocimum gratissimum in type-1 diabetic animal models. However, the mechanism of its antihyperglycaemic activity remains unknown. To shed more light on this activity, we decided to investigate the efficacy of the extract in type-2 model diabetic rats, for which few reliable data are currently available. The results from this study show...

Author(s): NELSON I. OGUANOBI, CHIOLI P. CHIJIOKE and SAMUEL I. GHASI

March 2012

Quality survey of some brands of artesunate-amodiaquine in Lagos drug market

With the advent of Artemisinin Combination Therapy (ACTs) as the recommended treatment protocol for malaria by WHO, the menace of substandard and counterfeit anti-malaria drugs have been on the rise. Artesunate-amodiaquine, like other ACTs, has been widely implicated in this menace due to the market value and affordability. 13 representative brands of Artesunate/Amodiaquine were procured from different outlets in urban...

Author(s): Teddy Ehianeta, Bidemi Williams, Jadesola Surakat, Nura Mohammed and Chimezie Anyakora

March 2012

Supplementation of Lycium barbarum polysaccharides protection of skeletal muscle from exercise-induced oxidant stress in mice

The present study aimed to determine whether Lycium barbarum polysaccharides (LBP) could limit oxidative stress induced by swimming exercise. The mice were randomly assigned to four groups, that is, one normal control group and three LBP treatment groups. LBP treatment groups (I, II and III) were administered with three different doses of LBP: 100, 200 and 300 mg/kg/day by gavage for 30 days. The normal...

Author(s): Duan Changbo and Sun Zhaojun

March 2012

Phloretin induced apoptosis of human hepatoma cells SMMC-7721 and its correlative biological mechanisms

In order to investigate the proliferative and apoptotic effects of phloretin on human hepatoma cell line SMMC-7721 and to explore the mechanisms of phloretin induced apoptosis, this research is set to observed morphological alterations with phase contrast and confocal microscopy, performed MTT assay, and detected apoptotic rates, cell cycle progression, mitochondrial trans-membrane potential and intracellular calcium...

Author(s): Hui Wang,#, Dianjun Wang#, Yabin Pu, Dengkui Pan,Weijun Guan and Yuehui Ma

March 2012

Properties of peroxidase from chewing stick miswak

Miswak is a chewing stick prepared from the roots, twigs or stems of Salvadora persica L.and widely used in Middle Eastern and Estern African cultures. Currently, its chemical components had antimicrobial and antioxidant activities. In the present study, peroxidase, as antioxidant and antibacterial enzyme, was screened in 4 parts of miswak and the level of peroxidase activity was recorded in the order of peel of...

Author(s): Saleh A. Mohamed, Abdulrahman L. Al-Malki, Jalaluddin A. Khan, Mansour I. Sulaiman and Taha A. Kumosani

March 2012

To evaluate likely antiamyloidogenic property of ferulic acid and baicalein against human islet amyloid polypeptide aggregation, in vitro Study

Aggregation of human islet amyloid polypeptide (hIAPP) as islet amyloid is associated with increased beta cell apoptosis and reduced beta cell mass in type 2 diabetes mellitus. Inhibition of the formation of β-amyloid fibrils, as well as the destabilization of preformed β-amyloid in the pancreas, would be attractive therapeutic targets for the treatment of diabetes mellitus. Using fluorescence spectroscopic...

Author(s): Seyyed Mehdi Mirhashemi and Mohammasd-Hossein Aarabi