Full Length Research Paper
Abstract
There is growing demand of polyherbal formulations in the world market. The present study aimed to design, develop, and evaluate the antiseptic activity of herbal wound pad Neemplast containing distillate of Neem leaves (Azadirachta indica) and Black pepper (Piper nigrum) and the oil of clove (Syzygium aromaticum) and Eucalyptus (Eucalyptus globules). The plants have been reported in the literature as having good antimicrobial, anti-oxidant and anti-inflammatory activity. Various formulation batches were prepared and evaluated for various parameters like colour, appearance, pH, weight per ml, assay identification and antimicrobial activity. The formulation of Batch# 358-K-12 was compared with the marketed preparation Sani-plast. It is a very good attempt to establish the herbal antiseptic wound pad containing distillate of Neem leaves Black pepper. The plant trials were conducted on a commercial scale machines in order to observe behavior and feasibility of machine with respect to new product formulation and also initiated analytical studies (qualitative and microbiological determination) in order to get the physical and chemical compatibility of formulation with the wound pad material. Implement current good manufacturing practice (cGMP) concept during all the manufacturing and packaging process. Neemplast wound pad was successfully designed and developed after extensive manufacturing and evaluation process by specialized techniques for evaluation of antiseptic activity in vitro.
Key words: Antiseptic, distillate, Piper nigrum, Azadirachta indica.
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