African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 8 September, 2013; 7(33)

September 2013

Protective effect of sildenafil against cysteamine induced duodenal ulcer in Wistar rats

The aim of the current study was to investigate the possible protective effect of sildenafil (SIL) on cysteamine induced peptic ulcer in Wistar rats. Rats were randomly divided into five groups; six animals each. Normal control group; in which animals received an aqueous solution of Tween 80 (1 ml/kg) as a vehicle, two doses orally at an interval of 4 h. SIL group, in which animals received 25 mg/kg SIL orally 30 min...

Author(s): Ahmed A. Elberry,

September 2013

The protective effect of Hypericum origanifolium in experimental renal ischemia/reperfusion injury in rats

Hypericum origanifolium leaf extract (HOE) is a medicinal plant extract containing many polyphenolic compounds. Polyphenolic compounds have high antioxidant potential. Reactive oxygen metabolites (ROMs) play a role in the pathogenesis of ischemia/reperfusion injury (I/R) in the kidney. This study was designed to determine the possible protective effect of HOE on renal I/R injury. Twenty four adult female Wistar...

Author(s): Hakan SENTURK, Sahin KABAY, Hilmi OZDEN, Gokhan BAYRAMOGLU, M. Cengiz USTUNER, Nilgun OZTURK, Gül GÜVEN, Ali KUTLU, Gokce BILGI, Derya USTUNER and H. Veysi GUNES

September 2013

In vitro protective effect of Schisandra chinensis extract against carbon tetrachloride–induced hepatotoxicity in common carp (Cyprinus carpio)

In the present study, in vitro hepatoprotective effect of Schisandra chinensis extract (SCE) was evaluated against carbon tetrachloride (CCl4)–induced hepatotoxicity in common carp. SCE (100, 200, and 400 µg ml-1) was added to the carp primary hepatocytes before (pre-treatment), after (post-treatment), and both before and after (pre and post-treatment) the exposure of the...

Author(s): Guo-jun Yin, Jia-hao Wang, Li-ping Cao, Jin-liang Du and Galina Jeney

September 2013

Irritant effects of Euphorbia prostrata

Irritant dermatological investigations of locally occurring Euphorbia prostrata were carried out to discover the irritant principle present in it. For this purpose, successive solvent extraction was carried out by using polar, non polar as well as intermediate polarity solvents for the extraction of active irritant compounds from the whole herb. Irritant potentials of these extracts were evaluated on...

Author(s): Syed Saeed-ul-Hassan, Muhammad Usman Bhatti, Muhammad Khalil-ur-Rehman, Uzma Niaz, Imran Waheed, Shahid Rasool, Sabiha Karim, Muhammad Asif Saeedand Imran Tariq

September 2013

Evaluation of wound healing activity of the polyherbal and Euphorbia hirta formulations

Evaluation of wound healing activity of polyherbal and Euphorbia hirta formulations was done. The study aimed at preparing a polyherbal formulation containing equal proportions of ethanolic extract of Tridax procumbens, Euphorbia hirta, Eclipta alba, dried rhizome ofCurcuma longa and gel of Aloe barbadensis. Excision wound, incision wound and granulaoma wound models were studied. In...

Author(s): Kuldeep Ganju and A. K. Pathak

September 2013

Design, development, and evaluation of antimicrobial activity of herbal antiseptic wound pad-neemplast

There is growing demand of polyherbal formulations in the world market. The present study aimed to design, develop, and evaluate the antiseptic activity of herbal wound pad Neemplast containing distillate of Neem leaves (Azadirachta indica) and Black pepper (Piper nigrum) and the oil of clove (Syzygium aromaticum) and Eucalyptus (Eucalyptus globules). The plants have been reported in the...

Author(s): Allah Nawaz , Kamran Alam,  Zeeshan Ahmed Sheikh, Naseema Khatoon, Syed Muhammad Amir, Khan Usmanghani and Irshad Ahmad

September 2013

Comparison of the effect of azithromycin versus erythromycin on gallbladder motility: A sonographic study

Erythromycin is a known prokinetic (cholecystokinetic) drug. Recently, erythromycin has been linked to the occurrence of arrhythmias and cardiac death due to QT prolongation. Azithromycin is similar to erythromycin in structure, but has the least arrythmogenic tendency among all the macrolides. This study was aimed at determining the comparative cholecystokinetic effects of erythromycin and azithromycin. Twenty four...

Author(s): A. C. Ugwu, K. K. Agwu and E. C. Umeh

September 2013

Antioxidative properties and inhibition of key enzymes linked to type-2 diabetes by snake tomato (Tricosanthes cucumerina) and two tomato (Lycopersicon esculentum) varieties

This study sought to compare the antioxidant properties [1,1-diphenyl–2 picrylhydrazyl (DPPH) and hydroxyl (OH) radicals scavenging abilities] and inhibition of Fe2+-induced lipid peroxidation and two key enzymes relevant to type-2 diabetes (α-amylase and α-glucosidase) of snake tomato (Trichosanthes cucumerina) with two tomato varieties [Lycopersicon esculentum Mill....

Author(s): A. O. Ademosun, G. Oboh, T. M. Adewuni, A. J. Akinyemi and T. A. Olasehinde