African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Full Length Research Paper

Cytotoxicity of extracts from fruit plants against leukemic cell lines

Chadarat Ampasavate1, Siriporn Okonogi1 and Songyot Anuchapreeda2*    
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand. 2Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.    
Email: [email protected]

  • Article Number - 75AA58229220
  • Vol.4(1), pp. 013-021, January 2010
  •  Published: 31 January 2010

Abstract

This study examined the antileukemic activity of non edible parts of 13 common Thai tropical fruits. Their ethanolic extracts were tested for cytotoxic effects on U937, K562, HL60, Molt 4 and normal human peripheral blood mononuclear cells (PBMCs). Three of 20 crude plant extracts (kaffir lime leaves, mangosteen peels, and wampee leaves) had strong cytotoxic effects on K562, U937, and Molt4 cells. The IC50 values of kaffir lime leaves on those cells were 26.1, 9.0 and 11.9 µg/ml respectively, whereas those of mangosteen peel were 23.6, 4.5 and 10.1 µg/ml, and those of wampee leaves were 71.9, 13 and 70.4 µg/ml. Furthermore, pomegranate peel extract had a potent cytotoxic effect on HL60 cells (IC50 of 8.0 µg/ml), but was non-toxic to normal PBMCs, indicating that as a potential source of antileukemic agents.

 

Key words: Fruit plants, cytotoxicity, leukemic cell line.

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