Abstract

In the present study, a new series of compounds (3 to 22) containing pyrazole moiety clubbed with 1,2-diazanaphthalene ring, structurally related to celecoxib and naproxen was synthesized. The compounds were evaluated for anti-inflammatory activity using carrageenan induced rat paw edema bioassay. Compounds showing marked anti-inflammatory activity were further tested for their analgesic, ulcerogenic and lipid peroxidation effect using naproxen as reference drug. The results showed that compounds 6, 13 and 14 exhibited good anti-inflammatory and analgesic activity with minimum gastric irritation. Compounds 13 and 14 emerged as potent anti-inflammatory (with percentage inhibition of 79.23 and 76) and analgesic agent (with percentage protection of 68.72 and 67.68) in the present study.

Key words: Cinnoline, pyrazole, anti-inflammatory activity, analgesic activity, lipid peroxidation.