African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2159

Table of Content: 15 February, 2012; 6(6)

February 2012

A combination of berberine and γ-oryzanol for hyperlipidemia therapy: An hypothesis

Hyperlipidemia has been thought to be a modifiable risk of coronary heart disease (CHD), and the patients generally require a chronic medication and a diet or lifestyle regulation to manage their hyperlipidemia. Meanwhile, the numbers of patients suffering from side effects are also increasing. Thus, development of novel, potent, safe and highly effective approaches to battle the world epidemics of hyperlipidemia is of...

Author(s): Yanna Pan, Shuai He, Guoping Liao, Lijing Chen and Zhongyi Zhang

February 2012

Drug eluting stent for restenosis diseases

Drug-eluting stents (DESs) have been prevailing for the treatment of CAD in the interventional cardiology world owing to their efficacy in significantly reducing restenosis. Current successful DES requires a polymer coating for drug delivery. Clinical trials examining several pharmaceutical agents, particularly sirolimus and paclitaxel have demonstrated marked reduction in restenosis following stenting. The development...

Author(s): Maulik Patel, Sanjay Patel, Nidhi Patel and Natvarlal Patel

February 2012

Expression of Gro (CXCL1) and SDF-1α (CXCL12) is differentially controlled by various intracellular signaling pathways in rat hepatocytes

Chemokines play key roles in physiological and pathological activities of liver diseases. This study aimed to examine the intracellular signaling pathways involved in regulation of expression of Gro (CXCL1) and SDF-1a (CXCL12). Hepatocytes were isolated from rat liver and were cultured on collagen Type-I. Initially, cells were suspended in inoculation medium and then were added to the pre-wetted plates. Then the...

Author(s): Gholamhossein Hassanshahi, Ali Shamsizadeh, Roshanak Hasheminasabzavareh, Ali Asghar Pourshanazari and Alan James Dickson  

February 2012

The in vivo antihypertensive effects of standardized methanol extracts of Orthosiphon stamineus on spontaneous hypertensive rats: A preliminary study

The purpose of this randomized control trial study was to investigate the effect of oralOrthosiphon stamineus (OS) on the systolic blood pressure of spontaneous hypertensive rats (SHR). The rats were divided randomly into five different groups of three rats each; group 1 received irbesartan (IR) drug (20 mg/kg) served as positive control group, group 2 received distilled water (control group) and group 3, 4...

Author(s): Nurul Alia Azizan, Rashidi Ahmad, Khaleed Mohamed, Mohd Zikri Ahmad and Zaini Asmawi

February 2012

Inhibitory effect of human angiogenesis inhibitor arresten on TGF-β1 expression in biliary endothelial cell

To investigate the inhibitory effect of arresten on TGF-β1 expression in biliary endothelial cells (BECs), BECs was collected by primary culture from human biliary scar tissue. The cells were cultured by different concentrations arresten. 3-(4,5-dimethythiazol-. 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to measure the proliferation rate of BECs, and the mRNA and protein expression of TGF-β1...

Author(s): Miaoyun Long, Honghao Li, Mingqing Huang, Dingyuan Luo, Xinzhi Peng and Peishun Wang

February 2012

Qualitative and quantitative evaluation of some herbal teas commonly consumed in Nigeria

Herbal tea can be use for therapeutic or nutritional purposes, depending on the chemical constituents present. This study aims at evaluating phytochemical, physicochemical parameters and elemental contents of herbal teas commonly consumed in Nigeria. Level of essential and toxic metals in medicinal plants is a matter of great concern all over the world. Six different brands of herbal teas were analysed in this study....

Author(s): A. Samali, Rukaiyatu A. Kirim and K. B. Mustapha

February 2012

Percutaneous absorption effects of Chinese herbal medicine

This study was carried out to evaluate the effects of Chinese herbal transdermal ointment on mastitis in the dairy cow and to select the best efficient formula for treating the disorder. With chlorogenic acid as a marker, using high performance liquid chromatography (HPLC), the contents of chlorogenic acid in permeate liquid were determined. Different skin permeation enhancing effects of Chinese herbal medicinal...

Author(s): Yongzhan Bao, Shaohua Zhang, and Wanyu Shi,

February 2012

The effect of iloprost on renal ischemia/reperfusion injury in an experimental rat model

In this study, the effect of iloprost on renal ischemia-reperfusion injury was investigated using an experimental rat model. Adult male Wistar rats subjected to 60 min of unilateral warm ischemia were allocated into sham (n = 4), control (n = 7) and iloprost (n = 7) groups. Iloprost was administered intravenously via the right external jugular vein at a dose of 2 ng/kg/min. Infusion started the same time as we clamped...

Author(s): K. Aykut, A. Kavala, E. Hazan, S. Sarioglu, S. Paksoy and A. Sisman

February 2012

Therapeutic effect of hyperbaric oxygen treatment combined with pharmacotherapy for sudden deafness: A retrospective study

To compare the therapeutic effect of hyperbaric oxygen (HBO) treatment and pharmacotherapy with that of pharmacotherapy alone in sudden deafness (SD) patients, and to evaluate the impact of therapeutic time window on the therapeutic effect, a total of 264 patients with SD were assigned into HBO group and control group. Patients in the HBO group received routine pharmacotherapy and HBO treatment, and those in the control...

Author(s): Huai Huang, Ronghao Yu, Jing Gu, Jianxin Wen and Shuilin Ye

February 2012

Anesthetics modulate oxidative stress during one-lung ventilation in lung cancer patients: Comparison of target-controlled propofol infusion and desflurane

Lung injury following thoracic surgery is a relatively uncommon disease, but has a major complication with high mortality. Many factors, including; ischemia reperfusion injury and the use of one-lung ventilation (OLV) are involved in this process. This study was conducted to compare the results of target-controlled infusion (TCI) of propofol versus desflurane in the aspect of oxidative stress in lung cancer patients...

Author(s): Şaban Yalçın, Enver Özgencil, Hacer Serdaroglu, Şirali Oba, Serkan Enön and Sacide Demiralp

February 2012

Casticin induces apoptosis and mitotic arrest in pancreatic carcinoma PANC-1 cells

Pancreatic cancer is one of the most malignant tumors that responded poorly to currently available chemotherapy. Casticin, a flavonoid compound, has been reported to induce apoptosis in various cancer cell lines. However, there is no report on the anti-pancreatic cancer potential of casticin. In the present study, we showed for the first time that casticin strongly inhibits the growth of PANC-1 pancreatic carcinoma...

Author(s): Chuan Ding, Muhammad Khan, Bin Zheng, Jingbo Yang, Lili Zhong and Tonghui Ma,

February 2012

Casticin induces apoptosis and mitotic arrest in pancreatic carcinoma PANC-1 cells

Pancreatic cancer is one of the most malignant tumors that responded poorly to currently available chemotherapy. Casticin, a flavonoid compound, has been reported to induce apoptosis in various cancer cell lines. However, there is no report on the anti-pancreatic cancer potential of casticin. In the present study, we showed for the first time that casticin strongly inhibits the growth of PANC-1 pancreatic carcinoma...

Author(s): Chuan Ding, Muhammad Khan, Bin Zheng, Jingbo Yang, Lili Zhong and Tonghui Ma,

February 2012

The evaluation of teratogenicity of nanosilver on skeletal system and placenta of rat fetuses in prenatal period

Nanosilver, comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that nanosilver has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings for wounds and burns. The teratogenicity potential for intraperitoneally dose of nanosilver had not...

Author(s): Mahmood Khaksary Mahabady

February 2012

Pyrazole incorporated 1,2-diazanaphthalene derivatives: Synthesis and in-vivo pharmacological screening as anti-inflammatory and analgesic agents

In the present study, a new series of compounds (3 to 22) containing pyrazole moiety clubbed with 1,2-diazanaphthalene ring, structurally related to celecoxib and naproxen was synthesized. The compounds were evaluated for anti-inflammatory activity using carrageenan induced rat paw edema bioassay. Compounds showing marked anti-inflammatory activity were further tested for their analgesic, ulcerogenic and lipid...

Author(s): Rajiv K. Tonk, Sandhya Bawa, Gita Chawla, Suresh Kumar, Himanshu Gupta and Obaid Afzal 

February 2012

Formulation, physical, in vitro and ex vivo evaluation of diclofenac diethylamine matrix patches containing turpentine oil as penetration enhancer

In this study, turpentine oil was used for enhancing the transdermal penetration of diclofenac diethylamine (DDEA) from matrix patches prepared using carboxypolymethylene (CPM) and ethyl cellulose (EC) by solvent evaporation technique. The drug matrix film was subjected to different physical testes like moisture content, moisture uptake and flatness, in vitro release and permeation studies and ex...

Author(s): Nauman Rahim Khan, Gul Majid Khan, Abdur Rahim Khan, Abdul Wahab, Muhammad Junaid Asghar, Muhammad Akhlaq and Abid Hussain

February 2012

Comparisons of the uses of flurbiprofen, lidocaine and dexamethasone in preventing injection pain caused by propofol

The objective of the study is to compare the different effects of flurbiprofen, lidocaine and dexamethasone on reduction of pain caused by propofol injection. 100 patients undergoing middle otoplasty surgery with general anesthesia were randomly assigned into four groups with 25 patients in each group. F, L, D, and C groups were treated with intravenous flurbiprofen 50 mg/5 ml, lidocaine 40 mg/5 ml, dexamethasone 5 mg/5...

Author(s): Xuezheng Zhang, Ying Zhou, Luowa Shu, Xuemei Fan and Bin Ding