Nine compounds were isolated from ethyl acetate and n-butanol extracts of Lysimachia clethroides and their structures were assigned from 1H- and 13C-NMR spectra and mass spectra as β-daucosterol (1), kaempferol (2), β-sitosterol (3), quercetin (4), stigmasterol (5),β-amyrin (6), betulinic acid (7), 3, 5,7,4'-tetrahydroxyflavanol (8) and α-amyrin (9). Compounds 7 and 8 were isolated from the plant for the first time, and also isolated fromLysimachia genus for the first time. Ethyl acetate and n-butanol extracts showed antioxidant activity, petroleum ether and n-butanol extracts showed a-glucosidase inhibitory activity. Compounds 2 and 4 had antioxidant activity with IC50 of 14.78±0.07 and 6.94±0.03 µg/ml, respectively, and α-glucosidase inhibitory activity with IC50 of 73.69±0.07 and 8.86±0.04 µg/ml, respectively. These results indicated that kaempferol and quercetin are the main active compounds in L. clethroides.
Key words: Lysimachia clethroides, chemical composition, antioxidant activity, α-glucosidase.
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0