African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2159

Table of Content: 15 December, 2012; 6(46)

December 2012

Study progress of homocellular and heterocellular gap junctions in vessel wall

There were four different degrees which were related to organs, tissues, cells and molecules in the study of physiopathologic process and treatment of vessel remodeling diseases. More people concentrated on the research of one kind of cell, for example, the vascular smooth muscle cell (VSMC) or adventitial fibroblast (AF) and their effect on the vessel rebuilding. However, the human body is an organic whole, so the...

Author(s): Yingkun He†, Kuo Gao†, Mingjing Zhao, Hong Chang, Yonghong Gao, Huan Lei, Yizhou Zhao and Shuoren Wang

December 2012

In vivo and in vitro antihelmintic activity of gemmotherapeutically treated Azadirachta indica (neem) against gastrointestinal nematodes of sheep and earthworms

In vivo and in vitro crude powder (CPE), native (NNE) and gemotherapeutic (GNE) extracts ofAzadirachta indica (neem) were studied to rationalize its traditional use. Live Haemonchus contortus and earthworms were used to access the in vitro and anthelmintic effect of crude extracts (NNE and GNE) of neem. The in vitro inhibitory effect of both GNE and NNE was evident in the...

Author(s): Zahoor-ul-Hassan M. Dogar, Faiza Aslam, Khalil-ur-Rahman, Muhammad Aamer  Aslam, Shazia Tabassum, Abdul  Rauf, Kafeel Ahmed, Muhammad Khalid Mukhtar, Zafar Iqbal Khan and Ehsan Elahi valeem

December 2012

Antimicrobial screening of Albizia lebbeck (l.) Benth. and Acacia leucophloea (Roxb.)

Albizzia lebbeck Benth. and Acacia leucophloea (Roxb.) Willd. are two very important medicinal plants growing wild in various parts of Pakistan. Various parts of both species are used by indigenous people as antimicrobial therapy however no detailed study exists regarding this activity. Crude methanolic extracts of pods, seeds, flowers and roots of Albizzia lebbeck Benth. and Acacia...

Author(s): Shakir Ahmad Shahid and Najma Firdous

December 2012

Systematic and ethnopharmacognostic investigation of selected medicinal plants of family Asteraceae

The present research project includes the family Asteraceae comprising the speciesCalendula arvensis L., Parthenium hysterophorus L. and Silybum marianum (L.) Gaertn. The present study was carried out to clear up the taxonomic position of the selected taxa and their authenticity. Medicinal plants face the problems in their identification due to confusion in nomenclature, taxonomic ranking and...

Author(s): Shabnum Shaheen, Mushtaq Ahmad, Nidaa Haroon, Farah Khan, Rana Abrar Hussain, Muhammad Zafar, Sehrish Ramzan, Rabail Ayub and Zaryab Khalid

December 2012

Inhibitory effect of oxymatrine on the proliferation and vascular endothelial growth factor A (VEGF-A) expression in human lung adenocarcinoma (SPC-A-1) cell

The aims of this study were to investigate the effect of oxymatrine (OMA) on human lung adenocarcinoma (SPC-A-1) as well as to explore the underlying mechanism. The inhibitory effects of OMA on the growth of SPC-A-1 cells were tested by using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, apoptosis assay and the expressions of vascular endothelial growth factor A (VEGF-A). OMA with...

Author(s): Rui Liang, Wei Zhang and Shoude Jin

December 2012

Prognostic significance of XRCC1, XDP and XRCC3 polymorphisms in non-small cell lung cancer patients with platinum-based chemotherapy

This study aims to investigate the prognostic role of XRCC1 and XRCC3 in non-small cell lung cancer (NSCLC) patients treated with chemotherapy. A total of 256 were consecutively selected between January 2003 to November 2006, and all patients were followed-up until November 2011. The genotyping of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met was analyzed by duplex polymerase-chain-reaction method. Individuals...

Author(s): Hong Luo, Xiao-ping Qiu, Mao-hui Feng, Shujuan Yang, Yan-cheng Xu

December 2012

Anti-inflammatory effect of oleanoic acid 28-O-β-D-glycopyranosyl ester isolated from Aralia cordata in activated HMC-1 cells

Aralia cordata is known in traditional Korean medicine as a remedy for arthritis. As a part of our program to screen medicinal plants for potential anti-inflammatory compounds, oleanoic acid 28-O-β-D-glycopyranosyl ester (OA) was isolated from the roots of Aralia cordata. So, the immune modulation molecular mechanism of OA isolated from A. cordata was studied.One of the possible mechanisms for...

Author(s): Ok-Hwa Kang, Suk-Hoon Kang, Sung-Bae Kim, Su-Hyun Mun, Yun-Soo Seo, Dae-Ki Joung, Ma-Ryong Kim, Dong-Won Shin, Kee-Tae Kweon and Dong-Yeul Kwon

December 2012

Small interfering RNA drug knockdown of EphrinB3 attenuates neuropathic pain after spinal cord injury in rats

Erythropoietin-producing hepatoma-amplified sequence (Eph) receptor tyrosine kinases and their cell-surface-bound ligands, the ephrins, function as a unique signaling system triggered by cell to cell interaction and have been shown to mediate neurodevelopmental processes. However, the role of Eph in spinal cord injury (SCI) was unclear. Here, the lentiviral expressing vectors, pGCSIL-green fluorescent protein (GFP)...

Author(s): Xiaodong Zhi, Mingyan Dong, Desui Yu, Yansong Wang, Da Huang and Gang Lv

December 2012

A poly-herbal formulation from traditionally used medicinal plants as a remedy for oral hygiene

Microorganisms play an important role in the development of periodontal diseases in human that lead to serious complications. Since ages, medicinal plants, singly or in combinations are used for the treatment of various dental disorders. However, their scientific validation and characterization is scarce. Therefore, the goal of this study was to develop knowledge based poly-herbal formulation as a remedy for oral...

Author(s): Priyanka Gupta, Vivek Kumar Gupta, Nimisha Tewari, Anirban Pal, Karuna Shanker, Sudha Agrawal, Rajesh Kumar Verma and Mahendra P. Darokar

December 2012

Antioxidant and a-glucosidase inhibitory compounds in Lysimachia clethroides

Nine compounds were isolated from ethyl acetate and n-butanol extracts of Lysimachia clethroides and their structures were assigned from 1H- and 13C-NMR spectra and mass spectra as β-daucosterol (1), kaempferol (2), β-sitosterol (3), quercetin (4), stigmasterol (5),β-amyrin (6), betulinic acid (7), 3, 5,7,4'-tetrahydroxyflavanol (8) and α-amyrin...

Author(s): Jin-feng Wei, Yi-bing Zhang and Wen-yi Kang