December 2012
Study progress of homocellular and heterocellular gap junctions in vessel wall
There were four different degrees which were related to organs, tissues, cells and molecules in the study of physiopathologic process and treatment of vessel remodeling diseases. More people concentrated on the research of one kind of cell, for example, the vascular smooth muscle cell (VSMC) or adventitial fibroblast (AF) and their effect on the vessel rebuilding. However, the human body is an organic whole, so the...
December 2012
In vivo and in vitro antihelmintic activity of gemmotherapeutically treated Azadirachta indica (neem) against gastrointestinal nematodes of sheep and earthworms
In vivo and in vitro crude powder (CPE), native (NNE) and gemotherapeutic (GNE) extracts ofAzadirachta indica (neem) were studied to rationalize its traditional use. Live Haemonchus contortus and earthworms were used to access the in vitro and anthelmintic effect of crude extracts (NNE and GNE) of neem. The in vitro inhibitory effect of both GNE and NNE was evident in the...
December 2012
Antimicrobial screening of Albizia lebbeck (l.) Benth. and Acacia leucophloea (Roxb.)
Albizzia lebbeck Benth. and Acacia leucophloea (Roxb.) Willd. are two very important medicinal plants growing wild in various parts of Pakistan. Various parts of both species are used by indigenous people as antimicrobial therapy however no detailed study exists regarding this activity. Crude methanolic extracts of pods, seeds, flowers and roots of Albizzia lebbeck Benth. and Acacia...
December 2012
Systematic and ethnopharmacognostic investigation of selected medicinal plants of family Asteraceae
The present research project includes the family Asteraceae comprising the speciesCalendula arvensis L., Parthenium hysterophorus L. and Silybum marianum (L.) Gaertn. The present study was carried out to clear up the taxonomic position of the selected taxa and their authenticity. Medicinal plants face the problems in their identification due to confusion in nomenclature, taxonomic ranking and...
December 2012
Inhibitory effect of oxymatrine on the proliferation and vascular endothelial growth factor A (VEGF-A) expression in human lung adenocarcinoma (SPC-A-1) cell
The aims of this study were to investigate the effect of oxymatrine (OMA) on human lung adenocarcinoma (SPC-A-1) as well as to explore the underlying mechanism. The inhibitory effects of OMA on the growth of SPC-A-1 cells were tested by using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, apoptosis assay and the expressions of vascular endothelial growth factor A (VEGF-A). OMA with...
December 2012
Prognostic significance of XRCC1, XDP and XRCC3 polymorphisms in non-small cell lung cancer patients with platinum-based chemotherapy
This study aims to investigate the prognostic role of XRCC1 and XRCC3 in non-small cell lung cancer (NSCLC) patients treated with chemotherapy. A total of 256 were consecutively selected between January 2003 to November 2006, and all patients were followed-up until November 2011. The genotyping of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met was analyzed by duplex polymerase-chain-reaction method. Individuals...
December 2012
Anti-inflammatory effect of oleanoic acid 28-O-β-D-glycopyranosyl ester isolated from Aralia cordata in activated HMC-1 cells
Aralia cordata is known in traditional Korean medicine as a remedy for arthritis. As a part of our program to screen medicinal plants for potential anti-inflammatory compounds, oleanoic acid 28-O-β-D-glycopyranosyl ester (OA) was isolated from the roots of Aralia cordata. So, the immune modulation molecular mechanism of OA isolated from A. cordata was studied.One of the possible mechanisms for...
December 2012
Small interfering RNA drug knockdown of EphrinB3 attenuates neuropathic pain after spinal cord injury in rats
Erythropoietin-producing hepatoma-amplified sequence (Eph) receptor tyrosine kinases and their cell-surface-bound ligands, the ephrins, function as a unique signaling system triggered by cell to cell interaction and have been shown to mediate neurodevelopmental processes. However, the role of Eph in spinal cord injury (SCI) was unclear. Here, the lentiviral expressing vectors, pGCSIL-green fluorescent protein (GFP)...
December 2012
A poly-herbal formulation from traditionally used medicinal plants as a remedy for oral hygiene
Microorganisms play an important role in the development of periodontal diseases in human that lead to serious complications. Since ages, medicinal plants, singly or in combinations are used for the treatment of various dental disorders. However, their scientific validation and characterization is scarce. Therefore, the goal of this study was to develop knowledge based poly-herbal formulation as a remedy for oral...
December 2012
Antioxidant and a-glucosidase inhibitory compounds in Lysimachia clethroides
Nine compounds were isolated from ethyl acetate and n-butanol extracts of Lysimachia clethroides and their structures were assigned from 1H- and 13C-NMR spectra and mass spectra as β-daucosterol (1), kaempferol (2), β-sitosterol (3), quercetin (4), stigmasterol (5),β-amyrin (6), betulinic acid (7), 3, 5,7,4'-tetrahydroxyflavanol (8) and α-amyrin...
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