African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

A novel green approach for the treatment of immature Schistosoma mansoni infection in mice with; Arabic gum (Acacia senegal); an antischistosomal agent

Rabab Selem
  • Rabab Selem
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Samia Rashed
  • Samia Rashed
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Mohammad Younis
  • Mohammad Younis
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Boshra Hussien
  • Boshra Hussien
  • Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
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Fatma Mohamed
  • Fatma Mohamed
  • Tropical Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
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Awatif Edrees
  • Awatif Edrees
  • Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
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Asmaa EL-kholy
  • Asmaa EL-kholy
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Gehan Rashed
  • Gehan Rashed
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Shereen Kishik
  • Shereen Kishik
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Ahlam Moharm
  • Ahlam Moharm
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Marwa Nageeb
  • Marwa Nageeb
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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Manal Kardoush
  • Manal Kardoush
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
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  •  Received: 19 October 2018
  •  Accepted: 08 November 2018
  •  Published: 22 November 2018

Abstract

Praziquantel (PZQ), the only common schistosocidal drug in use, is not efficacious for treatment of immature schistosomiasis infection. Arabic gum (AG) is a complex polysaccharide that acts as an anti-oxidant which modulates the inflammatory and/or immunological processes. This study explores for the first time, the antischistosomal properties of AG in mice infected with the immature stage of Schistosoma mansoni (S. mansoni). Mice were divided into four groups: control group (infected non- treated), AG treated group, PZQ treated group, and AG+PZQ treated group. Oral administration of AG in a dose of 1 g/kg body weight, daily for 3 consecutive weeks post-infection (PI) resulted in a statistically significant (P-value 0.002 and 0.008 respectively) lower worm burden in both AG group and AG+PZQ group compared to PZQ and control groups. AG+PZQ group always showed the best results when compared with other groups regarding tissue egg load and oogram pattern. AG, both alone and in combination with PZQ, decreased the granuloma number and diameter; with increasing the cellularity and the number of degenerated Schistosoma eggs inside granulomas. Results obtained by this work elucidated a promising AG bioactivity against S. mansoni immature stages and provided a platform for subsequent experimental studies to illuminate the academia more about this novel and " green" antischistosomal agent.

Key words: Schistosoma mansoni, immature stages, Arabic gum, antischistosomal agents, mice.

 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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