African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

A novel green approach for the treatment of immature Schistosoma mansoni infection in mice with; Arabic gum (Acacia senegal); an antischistosomal agent

Rabab Selem
  • Rabab Selem
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Samia Rashed
  • Samia Rashed
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Mohammad Younis
  • Mohammad Younis
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Boshra Hussien
  • Boshra Hussien
  • Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Google Scholar
Fatma Mohamed
  • Fatma Mohamed
  • Tropical Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
  • Google Scholar
Awatif Edrees
  • Awatif Edrees
  • Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Google Scholar
Asmaa EL-kholy
  • Asmaa EL-kholy
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Gehan Rashed
  • Gehan Rashed
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Shereen Kishik
  • Shereen Kishik
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Ahlam Moharm
  • Ahlam Moharm
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Marwa Nageeb
  • Marwa Nageeb
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar
Manal Kardoush
  • Manal Kardoush
  • Department of Parasitology, Faculty of Medicine, Benha University, Farid Nada Street, Banha, Egypt.
  • Google Scholar


  •  Received: 19 October 2018
  •  Accepted: 08 November 2018
  •  Published: 22 November 2018

References

Abdel-Salam A, Ammar N, Abdel-Hamid A (2008). Effectiveness of probiotic Labneh supplemented with garlic or onion oil against Schistosoma mansoni in infected mice. International Journal of Dairy Science 3(2):97-104.
Crossref

 

Ahmed AA, Fedail JS, Musa HH, Kamboh AA, Sifaldin AZ, Musa TH (2015). Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats. Pathophysiology 22(4):189-194.
Crossref

 

Ahmed AA, Fedail JS, Musa HH, Musa TH, Sifaldin AZ (2016). Gum Arabic supplementation improved antioxidant status and alters expression of oxidative stress gene in ovary of mice fed high fat diet. Middle East Fertility Society Journal 21(2):101-108.
Crossref

 

Ali BH, Ziada A, Blunden G (2009). Biological effects of gum arabic: a review of some recent research. Food and Chemical Toxicology 47(1):1-8.
Crossref

 

Al-Majed AA, Mostafa AM, Al-Rikabi AC, Al-Shabanah OA (2002). Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacological Research 46(5):445-51.
Crossref

 

Al-Olayan EM, El-Khadragy MF, Alajmi RA, Othman MS, Bauomy AA, Ibrahim SR, Moneim AE (2016). Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress. BMC Complementary and Alternative Medicine 16(1):434.
Crossref

 

Al-Yahya AA, Asad M (2016). Antiulcer activity of gum arabic and its interaction with antiulcer effect of ranitidine in rats. Biomedical Research 27(4).

 

Anderson D (1986). Evidence for the safety of gum arabic (Acacia senegal (L.) Willd.) as a food additive—a brief review. Food Additives and Contaminants 3(3):225-230
Crossref

 

Ballal A, Bobbala D, Qadri SM, Föller M, Kempe D, Nasir O, Lang F (2011). Anti-malarial effect of gum arabic. Malaria Journal 10(1):139.
Crossref

 

Botelho MC, Oliveira PA, Vieira P, Delgado MdL, Lourenço L, Lopes C, Correia da Costa JM (2010). Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms. Virulence 1(3):123-129.
Crossref

 

Botros S, El-Badrawy N, Metwally A, Khayyal M (1986). Study of some immunopharmacological properties of praziquantel in experimental schistosomiasis mansoni. Annals of Tropical Medicine and Parasitology 80(2):189-196.
Crossref

 

Botros S, William S, Hammam O, Holý A (2003). Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy) propyl] adenine against Schistosomiasis mansoni in mice. Antimicrobial Agents and Chemotherapy 47(12):3853-3858.
Crossref

 

Bowen T, Jenkins RH, Fraser DJ (2013). MicroRNAs, transforming growth factor beta‐1, and tissue fibrosis. The Journal of Pathology 229(2):274-285.
Crossref

 

Brinkworth RI, Prociv P, Loukas A, Brindley PJ (2001). Hemoglobin-degrading, Aspartic Proteases of Blood-feeding Parasites substrate specificity revealed by homology models. Journal of Bilogical Chemistry.
Crossref

 

Cançado JR, da Cunha AS, de Carvalho DG, Cambraia JS (1965). Evaluation of the treatment of human Schistosoma mansoni infection by the quantitative oogram technique. Bulletin of the WHO 33(4):557.

 

Cheever AW (1968). Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bulletin of the WHO 39(2):328.

 

Cheever AW (1969). Quantitative comparison of the intensity of Schistosoma mansoni infections in man and experimental animals. Transactions of the Royal Society of Tropical Medicine and Hygiene. 63(6):781-795.
Crossref

 

Chen B-L, Zhang G-Y, Wang S-P, Li Q, Xu M-H, Shen Y-M, Mu YB (2012). The combined treatment of praziquantel with osteopontin immunoneutralization reduces liver damage in Schistosoma japonicum-infected mice. Parasitology 139(4):522-529.
Crossref

 

Clark D, Gazi M, Cox S, Eley B, Tinsley G (1993). The effects of Acacia arabica gum on the in vitro growth and protease activities of periodontopathic bacteria. Journal of Clinical Periodontology 20(4):238-243.
Crossref

 

Colley DG (2014). Morbidity control of schistosomiasis by mass drug administration: how can we do it best and what will it take to move on to elimination? TROP. MED. health. 42(2Supplement):S25-S32.
Crossref

 

Ding L, Linsley P, Huang L, Germain R, Shevach E (1993). IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression Journal of Immunology 151(3):1224-1234.

 

Doenhoff MJ, Cioli D, Utzinger J (2008). Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Current Opinion in Infectious Diseases 21(6):659-667.
Crossref

 

Duvall RH, DeWitt WB (1967). An improved perfusion technique for recovering adult schistosomes from laboratory animals. American Journal of Tropical Medicine and Hygiene 16(4):483-486.
Crossref

 

Fedail JS, Ahmed AA, Musa HH, Ismail E, Sifaldin AZ, Musa TH (2016). Gum arabic improves semen quality and oxidative stress capacity in alloxan induced diabetes ratsAsian Pacific. Journal of Reproduction 5(5):434-441.

 

Gado AM, Aldahmash BA (2013). Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity Drug Design, Development and Therapy 7(3):1245.
Crossref

 

Harris H (1990). On the rapid conversion of haematoxylin into haematein in staining reactions. Journal of Applied Microscopic Laboratory Methods 3(3):777.

 

Holanda J, Pellegrino J, Gazzinelli G (1974). Infection of mice with cercariae and schistosomula of Schistosoma mansoni by intravenous and subcutaneous routes. Revista do Instituto de Medicina Tropical de Sao Paulo 16(3):132-134.

 

Kaddam L, FdleAlmula I, Eisawi OA, Abdelrazig HA, Elnimeiri M, Lang F, Saeed A M (2015). Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study. BMC Hematology 15(1):19.
Crossref

 

King CH, Dangerfield-Cha M (2008). The unacknowledged impact of chronic schistosomiasis. Chronic illness 4(1):65-79.
Crossref

 

King CL, Medhat A, Malhotra I, Nafeh M, Helmy A, Khaudary J, Brustoski K (1996). Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivityJournal of Immunology 156(12):4715-4721.

 

Lichtenberg FV (1962). Host response to eggs of S. mansoni: I. Granuloma formation in the unsensitized laboratory mouse. American Journal of Tropical Medicine and Hygiene 41(6):711.

 

Masson P (1929). Some histological methods: trichrome stainings and their preliminary technique. Journal Technology methods 12:75-90.

 

Matsumoto N, Riley S, Fraser D, Al-Assaf S, Ishimura E, Wolever T, Phillips AO (2006). Butyrate modulates TGF-β1 generation and function: Potential renal benefit for Acacia (sen) SUPERGUM™(gum arabic)?. Kidney International 69(2):257-265.
Crossref

 

Mohamed AH, Sharaf El-Din AT,Mohamed AM, Habib MR (2011). Tissue Responses Exhibited by Biomphalaria Alexandrina Snails from Different Egyptian Localities Following Exposure to Schistosoma Mansoni Miracidia. Exprimental parasitology 127(4):789-794
Crossref

 

Nasir O (2013). Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal)-What Can be Learned from Animal Experiments?. Kidney and Blood Pressure Research 37(45):269-279.
Crossref

 

Nasir O, Umbach AT, Rexhepaj R, Ackermann TF, Bhandaru M, Ebrahim A, Föller M (2012). Effects of gum arabic (Acacia senegal) on renal function in diabetic mice. Kidney and Blood Pressure Research 35(5):365-372.
Crossref

 

Nessim NG, Demerdash Z (2000). Correlation between infection intensity, serum immunoglobulin profile, cellular immunity and the efficacy of treatment with praziquantel in murine schistosomiasis mansoni. Arzneimitteforschung. 50(02):173-177.

 

Pellegrino J, Oliveira CA, Faria J, Cunha AS (1962). New approach to the screening of drugs in experimental schistosomiasis mansoni in mice. American Journal of Tropical Medicine and Hygiene 11(2):201-215.
Crossref

 

Pradeep A, Happy D, Garg G (2010). Short‐term clinical effects of commercially available gel containing Acacia arabica: a randomized controlled clinical trial. Australian Dental Journal 55(1):65-69.
Crossref

 

Pryde SE, Duncan SH, Hold GL, Stewart CS, Flint HJ (2002). The microbiology of butyrate formation in the human colon. FEMS Microbiology Letters 217(2):133-139.
Crossref

 

Rehan A, Johnson KJ, Kunkel RG, Wiggins RC (1985). Role of oxygen radicals in phorbol myristate acetate-induced glomerular injury. Kidney International 27(3):503-511.
Crossref

 

Ribeiro-dos-Santos G, Verjovski-Almeida S, Leite LC (2006). Schistosomiasis—a century searching for chemotherapeutic drugs. Parasitology Research 99(5):505.
Crossref

 

Ruth JH, Bienkowski M, Warmington KS, Lincoln PM, Kunkel SL, Chensue SW (1996). IL-1 receptor antagonist (IL-1ra) expression, function, and cytokine-mediated regulation during mycobacterial and schistosomal antigen-elicited granuloma formationJournal of Immunology 156(7):2503-2509.

 

Sadler CH, Rutitzky LI, Stadecker MJ, Wilson RA (2003). IL‐10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni. European Journal of Immunology 33(4):880-888.
Crossref

 

Saini ML, Saini R, Roy S, Kumar A (2008). Comparative pharmacognostical and antimicrobial studies of Acacia species (Mimosaceae). Journal of Medicinal Plants Research 2(12):378-386.

 

Savioli L, Daumerie D (2013). Sustaining the drive to overcome the global impact of neglected tropical diseases: second WHO report on neglected tropical diseases: WHO. 2.

 

Selem RF, Eraky MA (2015). Assessment of mefloquine in-vivo efficacy on juvenile and adult stages of Schistosoma haematobium (Egyptian strain). Parasitologists United Journal 8(1):60-67.
Crossref

 

Shear HL, Grinberg L, Gilman J, Fabry ME, Stamatoyannopoulos G, Goldberg DE, Nagel RL (1998). Transgenic mice expressing human fetal globin are protected from malaria by a novel mechanism. Blood. 92(7):2520-2526.

 

Singh B, Dubey S, Siddiqui M (2015). Antimicrobial activity of natural edible gums. Journal of Pharmaceutical Sciences 3(11):2217-2221.

 

Soliman R, Ismail O, Badr M, Nasr S (2017). Resveratrol ameliorates oxidative stress and organ dysfunction in Schistosoma mansoni infected mice. Exprimental parasitology 174:52-58.

 

Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J (2006). Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. The Lancet Infectious Diseases 6(7):411-425.
Crossref

 

Taylor M (2008). Global trends in schistosomiasis control. Bulletin of the WHO 86(10):738-738.
Crossref

 

Van Duivenvoorde LM, Han WG, Bakker AM, Louis-Plence P, Charbonnier L-M, Apparailly F, Toes RE (2007). Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms. Journal of Immunology 179(3):1506-1515.
Crossref

 

Verrecchia F, Mauviel A (2002). Transforming growth factor-β signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. Journal of Investigative Dermatology 118(2):211-215.
Crossref

 

Wang W, Wang L, Liang YS (2012). Susceptibility or resistance of praziquantel in human schistosomiasis: a review. Parasitology Research 111(5):1871-1877.
Crossref

 

West NP, Christophersen CT, Pyne DB, Cripps AW, Conlon MA, Topping DL, Clarke JM (2013). Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals. Exercise Immunology Review P 19.

 

Xuan NT, Shumilina E, Nasir O, Bobbala D, Götz F, Lang F (2010). Stimulation of mouse dendritic cells by Gum ArabicCellular Physiology and Biochemistry 25(6):641-648.