African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2145

Full Length Research Paper

Antioxidant and cicatrizing activity of the species Abarema cochliacarpos (Gomes) Barneby & J. W. Grimes

Saskya Araújo Fonseca
  • Saskya Araújo Fonseca
  • Centro Universitário Cesmac-CESMAC, Rua Cônego Machado, CEP: 57051-160, Maceió, AL, Brazil.
  • Google Scholar
J. R. M. Costa
  • J. R. M. Costa
  • Centro Universitário Cesmac-CESMAC, Rua Cônego Machado, CEP: 57051-160, Maceió, AL, Brazil.
  • Google Scholar
N. R. S. Gomes
  • N. R. S. Gomes
  • Centro Universitário Cesmac-CESMAC, Rua Cônego Machado, CEP: 57051-160, Maceió, AL, Brazil.
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Amanda Lima Cunha
  • Amanda Lima Cunha
  • Universidade Estadual de Alagoas-UNEAL, Rua Governador Luiz Cavalcante, S/N - Alto Cruzeiro, CEP: 57300-005, Arapiraca, AL, Brazil.
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João Gomes da Costa
  • João Gomes da Costa
  • Centro Universitário Cesmac-CESMAC, Rua Cônego Machado, CEP: 57051-160, Maceió, AL, Brazil.
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Thiago José Matos-Rocha
  • Thiago José Matos-Rocha
  • Centro Universitário Cesmac-CESMAC, Rua Cônego Machado, CEP: 57051-160, Maceió, AL, Brazil.
  • Google Scholar
Karwhory Wallas Lins da Silva
  • Karwhory Wallas Lins da Silva
  • Universidade Estadual de Alagoas-UNEAL, Rua Governador Luiz Cavalcante, S/N - Alto Cruzeiro, CEP: 57300-005, Arapiraca, AL, Brazil.
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Paulo Henrique Barcellos França
  • Paulo Henrique Barcellos França
  • Universidade Federal de Alagoas-UFAL, Av. Lourival Melo Mota, S/N - Tabuleiro do Martins, 57072-900, Maceió, AL, Brazil.
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Francisco Feliciano da Silva Júnior
  • Francisco Feliciano da Silva Júnior
  • Centro Universitário Cesmac-CESMAC, Rua Cônego Machado, CEP: 57051-160, Maceió, AL, Brazil.
  • Google Scholar
Antônio Euzébio Goulart Sant’Ana
  • Antônio Euzébio Goulart Sant’Ana
  • Universidade Federal de Alagoas-UFAL, Av. Lourival Melo Mota, S/N - Tabuleiro do Martins, 57072-900, Maceió, AL, Brazil.
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Aldenir Feitosa dos Santos
  • Aldenir Feitosa dos Santos
  • Centro Universitário Cesmac-CESMAC, Rua Cônego Machado, CEP: 57051-160, Maceió, AL, Brazil.
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  •  Received: 02 January 2019
  •  Accepted: 04 July 2019
  •  Published: 31 August 2019

Abstract

In equine clinics, skin injuries are some of the most frequently treated injuries, this research evaluated the healing potential and antioxidant activity of Abarema cochliacarpos in order to develop a pharmaceutical formulation for treating skin lesions in horses. Firstly, the antioxidant activity of several fractions was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical method and the thiobarbituric acid test. The determination of phenolic compounds was done by means of the Folin-Ciocalteau test. To assess the wound healing activity the dry powdered stem bark and the aqueous, ethanolic and propylene glycol extracts from the same plant, material were incorporated in a gel formulation and evaluated in equines with induced wounds. Results show that all obtained extracts and their fractions have antioxidant action. Regarding the healing evaluation in equines, the extracts tested and the dry powdered stem bark showed statistically significant activity in the contraction of wounds. Histological analysis revealed the powdered stem bark as the best treatment to induce healing of cutaneous lesions in horses. Experimental studies in animals with different dosages and formulations, besides the isolation of its chemical components, as a tool in the discovery of new healing agents or optimization of the existing ones is recommended.

Key words: Abarema cochliacarpos, antioxidant activity, wound healing activity.