African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2252

Full Length Research Paper

Influence of polyethylene glycol-8-lauryl ester in the structural lipid of the elastic liposomes

Raquel de Melo Barbosa*
  • Raquel de Melo Barbosa*
  • Biotechnological Process Department, College of Chemical Engineering, State University of Campinas, Campinas, SP, Brazil. Biochemistry Department, Institute of Biology, State University of Campinas, Campinas, SP, Brazil.
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Christine Lamenha Luna Finkler
  • Christine Lamenha Luna Finkler
  • Federal University of Pernambuco, Academic Centre of Vitória, PE, Brazil.
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Patrícia Severino
  • Patrícia Severino
  • Biotechnological Process Department, College of Chemical Engineering, State University of Campinas, Campinas, SP, Brazil.
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Maria Helena Andrade Santana1
  • Maria Helena Andrade Santana1
  • Biotechnological Process Department, College of Chemical Engineering, State University of Campinas, Campinas, SP, Brazil.
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  •  Received: 21 November 2013
  •  Accepted: 19 September 2014
  •  Published: 15 October 2014

Abstract

This study compared the physicochemical characteristics of conventional and elastic liposomes in terms of surfactant incorporation, flow rate, elasticity, mean diameter, phospholipid content and permeation capability. Surfactants were incorporated into conventional liposomes in order to enhance the transdermal transport of drugs through the stratum corneum. The unilamellar liposomes produced composed of egg phosphatidylcholine (PCegg) as the structural component and polyethylene glycol-8-lauryl ester (PEG8L) as the elastic component. Results showed fluidity increased of the lipid bilayer with surfactant incorporation, and particle integrity was preserved. These factors determined the ability of elastic liposomes to permeate nanoporous membranes. The elastic liposomes presented a size of ~100 nm and a polydispersity index of 0.38. The flow rate of the liposomes through membranes obeyed Darcy's law, with characteristics similar to those of water. The findings demonstrate the potential of elastic liposomes for transdermal drug administration.

 

Key words: Liposomes, surfactants, transdermal transport.