October 2014

Simultaneous determination of valsartan and hydrochlorothiazide in a tablet dosage form by liquid chromatography

A selective, rapid and accurate liquid chromatographic method is described for the simultaneous determination of valsartan (VAT) and hydrochlorothiazide (HTZ) in a solid dosage form. The chromatographic separation of two drugs were achieved on Lichrosphere CN column 250 mm × 4.0 mm,5 µm, Merck-India. The mobile phase consisting mixture of methanol, isopropyl alcohol and n-hexane in the ratio of 50:25:25 v/v...

Author(s): B. Udaykumar Rao and Anna Pratima Nikalje

October 2014

Effects of Salicornia herbacea L. supplementation on lipid peroxidation and antioxidative protein expression in rat skeletal muscle

Effects of Salicornia herbacea L. supplementation on lipid peroxidation and antioxidative protein expression in the skeletal muscle of rats was investigated in this study. Sixteen 6-week-old Sprague Dawley male rats were randomly divided into a control diet group (CG, n = 8) and an experimental diet group (EG, n = 8). The rats were given a high-fat diet (CG) or the 5% S. herbacea L. supplemented high-fat diet (EG) for 8...

Author(s): Daekeun Kwon, Junyong Kang and Youngju Song

October 2014

Influence of polyethylene glycol-8-lauryl ester in the structural lipid of the elastic liposomes

This study compared the physicochemical characteristics of conventional and elastic liposomes in terms of surfactant incorporation, flow rate, elasticity, mean diameter, phospholipid content and permeation capability. Surfactants were incorporated into conventional liposomes in order to enhance the transdermal transport of drugs through the stratum corneum. The unilamellar liposomes produced composed of egg...

Author(s): Raquel de Melo Barbosa,, Christine Lamenha Luna Finkler, Patrícia Severino, and Maria Helena Andrade Santana

October 2014

Preliminary investigations of the binding ability of lima bean (Phaseolus lunatus) starch in paracetamol tablets

The binding properties of starch obtained from Lima bean (Phaseolus lunatus) were evaluated. The starch from the seeds was extracted and the binding ability of its mucilage compared with that of maize starch mucilage in paracetamol based tablets at concentrations of 0, 2.5, 5, 7.5 and 10% w/v. The following properties of the starch powders were evaluated; organoleptic properties, microscopy and reaction with iodine...

Author(s): Eraga Sylvester Okhuelegbe, Erebor Joan Onyebuchi and Iwuagwu Magnus Amara