African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Full Length Research Paper

Physicochemical characterization and in-vitro evaluation of flubiprofen oral controlled release matrix tablets: Role of ether derivative polymer ethocel

Muhammad Akhlaq1,2*, Gul Majid Khan1, Abdul Wahab1, Hamdy Abdelkader3, Raid Alany2 Abid Hussain1 and Nauman Rahim Khan1
1Faculty of Pharmacy, Gomal University, D.I.Khan, KPK, Pakistan. 2School of Pharmacy, University of Auckland, Auckland, New Zealand. 3Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
Email: [email protected]

  •  Accepted: 07 June 2011
  •  Published: 31 July 2011

Abstract

The main aim of the study was to develop once-daily controlled release matrix tablet of the selected propionic acid derivative flubiprofen (100 mg) using ethyl cellulose ether derivative release controlling polymer. Preformulation factors, including solubility, powder flowability and compressibility, and loss on drying were studied. Hausner’s factor and angle of repose ranged from 1.10 to 1.25 and 25 to 29° respectively, indicating the best flowability and compressibility of the powder. Drug-polymer interaction was analyzed by particle size analysis, SEM and FTIR spectroscopy. Matrices were prepared by direct compression, with and without polymer. Effect of co-excipients like HPMC, starch and CMC, was studied on release behavior of the drug. The tablets were subjected to different physicochemical tests including hardness, friability, weight variation, % drug content, thickness and diameter with limits ranging from 6.4 ± 0.24 to 6.9 ± 0.44 kg/cm2, 0.22 ± 0.06 to 0.77 ± 0.03 w/w, 200 ± 1.3 to 203 ± 1.0 g, 98.30 ± 0.16 to 99.70 ± 0.64%, 2.1 ± 0.032 to 2.3 ± 0.020 mm and 4.2 ± 0.001 to 4.4 ± 0.001 mm respectively. In-vitrodrug release study was conducted in phosphate buffer (pH 7.4) and different kinetic parameters were applied. Ethocel FP polymer alone showed the best anomalous release with exponent  0.793 with the linearity  0.992, whereas the market brand released 90% of the drug after four hours with release exponent  0.210.

 

Key words: Drug delivery, flurbiprofen, ethyl cellulose ether derivative polymers, physicochemical, release kinetics.

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