Abstract

A nanosilver-epidermal growth factor sustained-release carrier was synthesized with the self-assembly method and characterized by transmission electron microscopy and Ultra violet (UV) spectrophotometry. The biological activity of the sustained release carrier was determined through cytological, bacteriological, and wound-healing experiments. The results show that the nanosilver-epidermal growth factor sustained-release carrier was well dispersed, with uniform particle size and that it had good antibacterial properties that were similar to those of nanosilver. Nanosilver-epidermal growth factor sustained-release carrier is superior to epidermal growth factors in effectively promoting cell division and proliferation. The results of wound-healing experiments show a curative effect.

Key words: Epidermal growth factor, nanosilver, antibacterial, wound, cell proliferation.