African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 22 February, 2013; 7(7)

February 2013

Toxicity of exhaust nanoparticles

The environmental problems in India are growing rapidly. The increasing economic development and a rapidly growing population that has taken the country from 300 million people in 1947 to more than one billion people today, is putting a strain on the environment, infrastructure, and the country’s natural resources. Industrial pollution, soil erosion, deforestation, rapid industrialization, urbanization, and...

Author(s): Durga Mohan, Devasena Thiyagarajan and Prakhya Balakrishna Murthy

February 2013

Phytochemistry and mode of action of some tropical spices in the management of type-2 diabetes and hypertension

Spices are important food supplements and/or food products, which have been used as flavouring agents and preservatives for thousands of years in tropical Africa, Asia and other parts of the world. They are well known for their medicinal properties, and their use in traditional systems of medicine has been on record for a long time. Although, epidemiological and clinical studies have indicated that spices are important...

Author(s): Stephen Adeniyi Adefegha and Ganiyu Oboh

February 2013

Design, characterization and evaluation of PEGylated-mucin for oral delivery of metformin hydrochloride

The study was undertaken to formulate and evaluate PEGylated-mucin matrices-based solid microparticles for oral administration of metformin hydrochloride (MTH). PEGylated-mucin matrices formulated with PEG-2000 and Mucin were used to prepare metformin-loaded PEGylated-mucin using solvent interaction method. Characterizations based on size and morphology, zeta potential and polydispersity index, loading and encapsulation...

Author(s): Momoh M. A., Adedokun M. O., Adikwu M. U., Kenechukwu F. C., Ibezim E. C. and Ugwoke E. E.

February 2013

Association of the p53 codon 72 polymorphism with breast cancer in central part of Iran

The tumor suppressor gene protein 53 (p53) plays a general role in cell cycle control, the initiation of apoptosis and in DNA repair. The human p53 gene is mutated and accumulated in more than 50% of cancers. Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. This study was aimed at investigating the possible association between p53 Arg72Pro polymorphism and susceptibility to...

Author(s): Hojjat Rouhi Boroujeni, Mehrdad Karimi, Saadat Moshkelani and Pouya Parsaei

February 2013

Chemical composition, antioxidant activity and cytotoxicity of the essential oils of the leaves and stem of Tarchonanthus camphoratus

The aim of this study was to investigate the chemical composition, antioxidant potential and cytotoxicity of the essential oil of the fresh leaf, dry leaf and dry stem of Tarchonanathus campharatus. The antioxidant activity of the oils were examined by the 1,1-Diphenyl-2-picryl-hydrazil (DPPH), 2’-azinobis-(3-ethylbenzothiazo­line-6-sulfonic acid) (ABTS.+), nitric oxide radical scavenging and...

Author(s): Sarah K. Nanyonga, Andy Opoku, Francis B. Lewu, Adebola O. Oyedeji and Moganavelli Singh

February 2013

Neuronal activities of berberine in Schistosoma mansoni-infected mice

The present study aimed to investigate the neuronal activities of berberine (BER) againstSchistosoma mansoni-induced infection in mice. Animals were divided into four groups. Group I served as a vehicle control. Group III was gavaged with 100 µl of 12 mg/kg berberine chloride for 10 days. Group II and Group IV were infected with 100±10 S. mansoni cercariae, and on day 46 p.i. with S....

Author(s): Amira A. Bauomy, Marwa S. M. Diab, Ahmed E. Abdel Moneim, Mohamed A. Dkhil, and Saleh Al-Quraishy

February 2013

Physiochemical, minerals, phytochemical contents, antimicrobial activities evaluation and fourier transform infrared (FTIR) analysis of Hippophae rhamnoides L. leaves extracts

The present research study was designed to characterize the physiochemical, minerals, phytochemicals, antimicrobial activities and FTIR spectra analysis of various extracts ofHippophae rhamnoides L. leaves. The physiochemical and mineral content of H. rhamnoides L. leaves revealed that fiber was 18.0 ± 2.64%, protein was 10.45 ± 0.88% and carbohydrate value calculated was found to be 68.75...

Author(s): Bashir Ahmad and Javid Ali,

February 2013

Effect of Persian shallot (Allium hirtifolium Boiss.) extract on glucokinase (GCK), glycogen phosphorylase and phosphoenolpyruvate carboxykinase (PEPCK) genes expression in diabetic rats

There has been a growing interest in hypoglycaemic agents from natural products, especially those derived from plants. In the current survey, hypoglycaemic properties of Persian shallot (Allium hirtifolium Boiss) was evaluated by studying mRNA expression levels of the key enzymes involved in carbohydrate metabolism in liver, Glucokinase (GCK), phosphoenolpyruvate carboxykinase (PEPCK), and glycogen...

Author(s): Mehdi Mahmoodi, Seyed-Mostafa Hosseini-Zijoud, Mohammad Kazemi Arababadi, Hossein Khorramdelazad, Hemen Moradi-Sardareh, Younes Moradi, Gholamhossein Hassanshahi, Behrooz Hashemi, Hasan Ghasemi, Mohammad-Nabi Moradi and Nejad Mohamadi

February 2013

Detection, biological effectiveness, and characterization of nanosilver-epidermal growth factor sustained-release carrier

A nanosilver-epidermal growth factor sustained-release carrier was synthesized with the self-assembly method and characterized by transmission electron microscopy and Ultra violet (UV) spectrophotometry. The biological activity of the sustained release carrier was determined through cytological, bacteriological, and wound-healing experiments. The results show that the nanosilver-epidermal growth factor sustained-release...

Author(s): Hui-Qing Xie, Jiang-Lin Zhou, Jian-da Zhou, Yao Chen and Long-Yu Jin