African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2191

Full Length Research Paper

Effects of Jatropha gossypiifolia L. on the blood pressure and vascular reactivity of rats

Selma do Nascimento Silva*
  • Selma do Nascimento Silva*
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Iracelle Carvalho Abreu
  • Iracelle Carvalho Abreu
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Maria do Socorro de Sousa Cartagenes
  • Maria do Socorro de Sousa Cartagenes
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Maisa Carvalho Rezende
  • Maisa Carvalho Rezende
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Karla Frida Torres Flister
  • Karla Frida Torres Flister
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Cristiane Tavares Machado
  • Cristiane Tavares Machado
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Roberto Sigfrido Gallegos Olea
  • Roberto Sigfrido Gallegos Olea
  • Department of Chemistry, Laboratory of Natural Products, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Sonia Maria de Farias Freire
  • Sonia Maria de Farias Freire
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Marilene Oliveira da R. Borges
  • Marilene Oliveira da R. Borges
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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Antonio Carlos Romao Borges
  • Antonio Carlos Romao Borges
  • Department of Physiological Sciences, Pharmacology Research and Post-Graduate Laboratory, Federal University of Maranhao, Av. Portugueses, S/N, 65085-580, Sao Luis, Maranhao, Brazil.
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  •  Received: 29 November 2014
  •  Accepted: 02 March 2015
  •  Published: 22 March 2015

Abstract

This work investigated the effects of the ethanolic extract (EEJg) of aerial parts of Jatropha gossypiifolia L. and its aqueous (AFJg) and chloroformic (CFJg) fractions on the blood pressure and vascular reactivity (VR) in normotensive Wistar rats (NWR) and spontaneously hypertensive rats (SHR). In anaesthetized NWR, the EEJg and its fractions reduced mean blood pressure (MAP). The oral administration of EEJg (100 mg/kg/bw), for 8 weeks, did not alter MAP and heart rate in the non-anesthetized SHR. VR was determined in mesenteric artery rings, with the EEJg and fractions inhibiting the contractile responses to noradrenaline (NA, 10-9 to 10-4 M) in NWR, but not in SHR. In addition, the CFJg inhibited the contractile response to calcium (CaCl2, 10-6 to 10-2 M). These results suggest that J. gossypiifolia L. has no effect on the hypertensive factors in SHR, which is a model of polygenic hypertension, but indicate the presence of substances with hypotensive activity, which act directly on the adrenoceptor and/or decrease calcium mobilization in NWR.

Key words: Jatropha gossypiifolia L., vascular reactivity, hypertension, calcium, mesenteric artery.