African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2191

Full Length Research Paper

Assessment of a modified release verapamil hydrochloride (HCl) matrix compacts: Effect of formulation composition on the in vitro release kinetic

J. Rojas1*, J. Aristizabal and J. Sanchez
Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia, Medellin, Colombia.  
Email: [email protected]

  •  Accepted: 18 April 2013
  •  Published: 22 April 2013


Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model was used to fit the dissolution data since it presented the best fitting characteristics. A cubic model predicted the best formulation of verapamil.HCl containing carnauba wax, hydroxypropyl methyl cellulose and Avicel_PH101 at the 40, 20 and 40% levels, respectively. Validation runs confirmed the accuracy of the cubic models which include these three components.


Key words: Verapamil, controlled-release preparations, non-linear models, experimental design.