April 2013
Pharmacokinetic study of vinorelbine in Chinese patients with non-small-cell lung cancer by high-performance liquid chromatography (HPLC) with fluorescence detection
To investigate the pharmacokinetics of vinorelbine in Chinese subjects with non-small-cell lung cancer (NSCLC), a high-performance liquid chromatographic method using fluorescence detection was established to determine the concentrations of vinorelbine in human blood and plasma. Samples were collected from 10 Chinese patients with NSCLC after intravenous infusion of 40 mg vinorelbine. Pharmacokinetic parameters were...
April 2013
Hepatoprotective effect of Barrisal (herbal drug) on carbon tetrachloride induced hepatic damage in rats
Barrisal is an herbal preparation of Hamdard Laboratories (Waqf) Pakistan that has been used as hepatoprotective agent. In this study, the protective effects of Barrisal against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. Four groups (I, II, III, IV) of Sprague-Dawley (SD) rats were used and Groups I and II were orally fed with saline and Barrisal (10 ml/kg),...
April 2013
The biochemical changes in rats' blood serum levels exposed to different gamma radiation doses
This study aimed to address the different gamma radiations doses effect on the liver and kidney function of rats: in vivo. A total of 60 healthy male Wistar-Kyoto rats were whole body gamma irradiated with Co 60 source with 0.883 cG/sec dose rate at the beginning of the experiment. The rats were randomly divided into 4 gamma-irradiation groups (25, 50, 75 and 100 Gy) The serum levels of activity of alanine...
April 2013
Assessment of a modified release verapamil hydrochloride (HCl) matrix compacts: Effect of formulation composition on the in vitro release kinetic
Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model...
April 2013
Effect of dose on disposition kinetics of isometamidium chloride/hydrochloride in trypanosomiasis induced calves
Effect of dose on disposition kinetics of isometamidium (ISMM) in Indian buffalo calves was studied in view of limited applications of the drug in India. Buffalo calves were pre grouped and trypanosomiasis was induced using Trypanosoma evansi. ISMM was administered intravenously at 0.25, 0.5 and 1 mg/kg (body weight) to the grouped animals. Blood samples were collected at 0.08, 0.16, 0.33, 0.66, 1, 2, 4, 6, 8, 12, 24...
April 2013
Formulation of pyridoxine hydrochloride sustained release capsules: Effect of propylene glycol co-solvent on the in vitro release
The objectives of the present study were to formulate sustained release pyridoxine hydrochloride capsules and to study the effect of propylene glycol co-solvents on the in vitroproperties of the capsules. All batches of formulations were made with fixed concentrations of binder-disintegrants, diluents and equal load of active pharmaceutical ingredient. The granules were prepared by wet granulation using propylene...
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