African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2272

Full Length Research Paper

Effect of the plant growth regulator (4-Chlorophenoxy acetıc acıd) ınto the oxıdatıve stress parameters in rat liver

Duygu Tozcu Altın1, ÇiÄŸdem Özer 1*, Ediz YeÅŸilkaya3, Aydan Babül1, Aysun Bideci2and Peyami Cinaz2
1Department of Physiology, Faculty of Medicine, Gazi University, Ankara, Turkey. 2Department of Pediatric Endocrinology, Faculty of Medicine, Gazi University, Ankara, Turkey. 3Department of Pediatric Endocrinology, Gülhane Military Medical Academy, Ankara, Turkey.
Email: [email protected]

  •  Accepted: 24 November 2011
  •  Published: 15 December 2011


4-Chlorophenoxy acetic acid (4-CPA) is one of the plant growth regulators that are widely used in greenhouses to increase yield and the quality of products. Plant growth regulators do not produce significant effects on organisms; however, their remnants on plants due to either high dose or inappropriate use may lead to certain adverse effects on humans. High doses of 4-CPA have been reported to cause hepatocellular necrosis. In our study, we investigated the oxidant and anti-oxidant parameters in the liver tissues of male and female rats exposed to 4-CPA before sexual maturity. The study was implemented on 20 day-old, 80 Wistar albino rats. Forty rats received 4-CPA/day until 50 days of age. The rats were randomized into five groups (a control group, a saline group and three 4-CPA groups that received 25 to 50 to 100 mg/kg/day, respectively); and each group were further divided according to gender, making a total of 10 groups. Comparison of each gender in control and saline groups showed no difference for MDA, GSH and NOx levels. However, exposure to 4-CPA caused a dose-dependent increase in MDA and a decrease in NOx levels. These findings may be the result of 4-CPA’s effects on lipid peroxidation and inflammatory reactions in liver tissue.


Key words: Liver, plant growth regulator, endocrine disrupters, oxidative stress, 4-Chlorophenoxy acetic acid (4-CPA).