African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2162

Full Length Research Paper

Some in vitro and pharmacodynamic evaluation of indomethacin solid lipid microparticles

N. C. Obitte1*, S. A. Chime1, A. A. Magaret1, A. A. Attama2, I. V. Onyishi1 and S. A. Brown3
1Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria. 2Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria. 3Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Rivers State, Nigeria.
Email: [email protected]

  •  Accepted: 29 June 2012
  •  Published: 15 August 2012

Abstract

The purpose of this study was to investigate some in vitro and pharmacodynamic properties of indomethacin-loaded solid lipid microparticles (SLMs). A blend of homolipid from Caprahircus and Phospholipon® 90G comprised of the lipid matrix. The SLMs were prepared by the hot homogenisation technique. The effects of Carbosil® and sodium chloride on the release profile and particle size of the SLMs were investigated. The anti-inflammatory and gastro-protective characteristics of the SLMs were also studied. The particle size ranged from 5.0 to 20 µm. The encapsulation efficiency ranged from 46 to 72%; with sodium chloride-containing batches recording highest values. Maximum drug release was within 80 min. Significant (P < 0.05) anti-inflammatory effect was exerted by the SLM. Relative high ulcer index associated with unformulated indomethacin powder and the absence of gastric lesions in rats that received oral administration of SLM affirmed the gastro-protective potential of the SLM. In conclusion, improved anti-inflammatory and gastro-protective effects were achieved with indomethacin-loaded SMLs. 

 

Key words: Anti-inflammatory, gastro-protective, solid lipid microparticles (SLMs).

 

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