African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Full Length Research Paper

Vanadyl-poly(g-glutamic acid) complexes as oral therapeutic agents for the treatment of type 1 like diabetic mice

Subarna Karmaker1,2, Tapan K. Saha1, 2*, Yutaka Yoshikawa2 and Hiromu Sakurai2
1School of Physical Education and Sports, Harran University, Şanlıurfa, Turkey. 2School of Physical Education and Sports, Muğla University, Muğla, Turkey.
Email: [email protected]

  • Article Number - AD8D73125596
  • Vol.4(5), pp. 235-243 , May 2010
  •  Accepted: 23 March 2010
  •  Published: 31 May 2010

Abstract

In developing new insulin-mimetic vanadyl complexes with various ligands including biodegradable polymers, we prepared and characterized three VO(g-pga) complexes in solution and evaluated their in vitro insulin-mimetic activities and in vivo anti-diabetic effects in streptozotocin (STZ)-induced type 1 like diabetic mice (STZ-mice). All three VO(g-pga) complexes normalized the hyperglycemia in STZ-mice within 14 d when administered orally at doses of 10 mg V kg–1 body mass for 28 d. In addition, the impaired glucose tolerance, elevated HbA1c levels and metabolic syndromes were significantly improved in VO(g-pga) complexes-treated STZ-mice relative to those administrated with saline and VS. Vanadium was distributed in the tissues examined in the following decreasing order: bones, liver, muscles, spleen, heart, kidneys, brain, lungs and pancreas. VO(g-pga) complexes in which -pga having average molecular weight 480 - 4700 kDa are promising oral therapeutic agents for the treatment of type 1 diabetic animals.

 

Key words: Vanadyl-poly(g-glutamic acid) complex, STZ-mice, drug delivery system, diabetes, hyperglycemia.