May 2010
Efficacy and safety of long-acting risperidone on early onset schizophrenia in adolescent patients
The present study is aimed at evaluating the efficacy and safety of long-acting risperidone on early onset schizophrenia in adolescent patients. A total of 31 adolescent patients (13 - 18 years) with schizophrenia met the DSM-IV-TR criteria for schizophrenia and their symptoms were stable when orally taking risperidone or olanzapine. They were admitted into a 24 week, open-label study on the long-acting...
May 2010
Phenolic content and antioxidant activity of crude and fractionated extracts of Pereskia bleo (Kunth) DC. (Cactaceae)
The total phenolic content of the extracts of Pereskia bleo were assessed by the Folin-Ciocalteau’s method while the antioxidant activities were determined by three different assays, namely scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, reducing power assay and ß-carotene method. In the present study, the ethyl acetate extract exhibited the highest total phenolic content...
May 2010
Analysis of some lipid parameters following lithium administration
Lithium is a drug of choice for treatment of some psychological disorders including manic depression. Wistar Rats (male and female) were housed in individual improvised cages. The rats were acclimatized for two weeks after which they were randomly grouped into 3 viz control, lithium treated and lithium with saline treated group and treated for four weeks. The lithium treated group received 40 mM lithium bicarbonate per...
May 2010
Safety research on community pharmacies in Kocaeli
The aim of this research was to understand the precautionary measures of pharmacies in terms of safety issues of service. There are 322 community pharmacies in Kocaeli. Cluster sampling was used to select the community pharmacies included into the study. Four of eight regions were selected to this end. Throughout December 2005, face-to-face questionnaires were administered in 156 of...
May 2010
Synthesis and antimicrobial screening of peptidyl derivatives of bromocoumarins/methylimidazoles
May 2010
Gastroprotective effect of Phyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats
The main objective of this study is to evaluate the gastroprotective activity of thePhyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats. Six groups of Wistar rats were pre-treated, respectively, with distilled water; omeprazole 20 mg/kg; and 250, 500, 750 and 1000 mg/kg P. niruri leaf extract 30 min before oral administration of absolute ethanol to generate gastric...
May 2010
Vanadyl-poly(g-glutamic acid) complexes as oral therapeutic agents for the treatment of type 1 like diabetic mice
In developing new insulin-mimetic vanadyl complexes with various ligands including biodegradable polymers, we prepared and characterized three VO(g-pga) complexes in solution and evaluated their in vitro insulin-mimetic activities and in vivo anti-diabetic effects in streptozotocin (STZ)-induced type 1 like diabetic mice (STZ-mice). All three VO(g-pga) complexes normalized the hyperglycemia in...
May 2010
Identification and spectrophometric determination of hydroquinone levels in some cosmetic creams
Hydroquinone, a dihydroxylated benzene derivative is used therapeutically as a topical agent for the treatment of certain skin conditions. Ten (10) cosmetic creams containing hydroquinone were randomly sampled based on consumer demand from the open market in Jos, Plateau State. The labels on the packages noticeably did not indicate the levels of hydroquinone present. The creams were subjected to colour and...
May 2010
Anti-helicobacter pylori and protective effects of aqueous Fumaria vaillantii L extract in pylorus-ligated, indomethacin- and toxic-induced ulcers in rats
This paper evaluated anti-ulcer, anti-secretory and anti-helicobacter pylori effects of folkloric medicinal plant, Fumaria vaillantii L., in rats. Different toxic agents; ethanol (80%), NaOH (0.2 mol/L), NaCl (25%) and indomethacin (30 mg/kg, body weight) were used to produce acute gastric ulceration in rats. Anti-secretory studies were undertaken by using pylorus-ligation, Shay rat...
May 2010
Antinociceptive and anti-inflammatory properties of Gunnera perpensa (Gunneraceae)
Gunnera perpensa, which belongs to the Gunneraceae family, is used in folk medicine to relieve rheumatoid pain, facilitate childbirth and for healing wounds. In this study, the antinociceptive and anti-inflammatory properties of this plant extracts were evaluated using the abdominal constriction, hot-plate, formalin, hyperalgesia and fresh egg albumin-induced inflammation. The extracts were administered...
May 2010
Treatment with extracts of Eugenia jambolana seed and Aegle marmelos leaf prevents hyperglycemia and hyperlipidemia in alloxan induced diabetic rats
Eugenia jambolana and Aegle marmelos are used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of a combined aqueous extracts of E. jambolana and A. marmelos (EA) on alloxan induced diabetic rats. The diabetes induced animals were fed with...
May 2010
Effect of fractionation on antiradical efficacy of ethyl acetate extract of Terminalia chebula Retz.
There is currently an upsurge of interest in phytochemicals as new sources of natural antioxidants. The aim is to use them in foods and pharmaceutical preparations in order to replace synthetic antioxidants, which are being restricted due to their potential health risks and toxicity. The relative levels of antioxidant activity and the total phenolic content of ethyl acetate extract/fractions of Terminalia...
May 2010
In vitro activity of cranberry extract against etiological agents of urinary tract infections
Cranberries have long been the focus of interest for their beneficial effects in preventing urinary tract infections (UTIs). The objective of this study was to determine in vitro activity of cranberry extract on common etiologic agents of urinary tract infections isolated from patients. Filter sterilized methanol extract of cranberry was prepared and used in the present study. The minimum inhibitory...
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