Abstract

This study aimed to investigate the effects of eleven chemical constituents from Radix isatidis(Indigowoad root) on the inhibition of a mouse lung-adapted variant of the influenza A1 virus (FM1) and respiratory syncytial virus (RSV) in vitro and to identify the effective antiviral components of R. isatidis. The inhibitory effects of these chemical constituents against FM1 and RSV were measured using the methyl thiazolyl tetrazolium (MTT) assay. Viral suppression rates were used as an evaluation index to compare the antiviral activity of the eleven chemical constituents. The results showed that the eleven chemical constituents exerted stronger inhibitory effects on FM1 as compared to RSV. Among these chemical constituents, indirubin and isovitexin had the strongest antiviral activity.

Key words: Radix isatidis (Indigowoad root), antiviral, activity screening.