African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 October, 2011; 5(16)

October 2011

Phytochemicals and inorganic profile of Calendula officinale and Sonchus asper

The present work was carried out to investigate the quantitative determination of crude phytochemicals (alkaloids, flavonoids and saponins), heavy metals and inorganic constituents in Calendula officinale and Sonchus asper. Heavy metals were determined by atomic absorption spectrophotometer and inorganic constituents by the available methods (AOAC, 2000). The studied plants showed variable amount of...

Author(s): Iqbal Hussain, Riaz Ullah, , Naeem khan, Sultan Ayaz,Shabir Ahmad, Shanzeb, Majed Ahmed, Pir Tariq Hasan, and Farhat Ali Khan 

October 2011

In vivo toxicity study of Ganoderma boninense

Ganoderma boninense (Pat.) is widely used in China and other countries of the Orient in the traditional treatment of many ailments. However, there is little toxicological data available regarding safety of this mushroom. The present study describes the toxicity of methanol extract of G. boninense in Artemia salina. The methanol extract of G. boninense was tested for in vivo brine...

Author(s): S. Sasidharan, O. Jinxuan,  L. Yoga Latha and S. Amutha,

October 2011

In-vivo studies on the pharmacokinetics of berberine on middle cerebral artery occlusion rat and sham-operated rat

The present study aims to investigate the influence of cerebrovascular disease and herb prescription on the pharmacokinetics of berberine. In the designed study, rats were divided into middle cerebral artery occlusion (MCAO) group and sham-operated group. Each group contained two subgroups: Oral administration of Huang-Lian-Jie-Du-Tang (HLJDT) (is equal to 258 mg berberine/kg body weight) and pure berberine...

Author(s): Linmei Pan, Bihan Qiu, Huan Li, Mingfei Zeng, Huaxu Zhu, Qichun Zhang, Liwei Guo and Zhilei Qian

October 2011

A study on the regenerative potential of the root and leaf extracts of Elephantopus scaber L.: An antidiabetic approach

Ayurveda and other Indian literatures mentioned the use of plants in the treatment of various human ailments. Plants have been used by man as natural remedies from time immemorial.Elephantopus scaber L., belonging to the family Asteraceae, is a small perennial herb located in tropical climates. Anachuvady as it is called literally means “elephant’s foot”. Its leaves seem to grow as a bunch protruding...

Author(s): P. Daisy, Cecilia Edel Priya and Lily Vargese

October 2011

Evaluation of the antihypertensive activity of total aqueous extract of Justicia secunda Valh (Acanthaceae)

Our study aim at contributing to establish the scientific basis for the use of Justicia secundaVahl. (Acanthaceae) in the traditional treatment of hypertension in Côte d’Ivoire. We used a total aqueous extract of leaves of J. secunda (TAEJS). The experimental device used for recording blood pressure in the rabbit is based on the principle of Ludwig mercury manometer. TAEJS between 5.55 and...

Author(s): Pierre Manda, Danho Pascal Abrogoua, Calixte Bahi, Djédjé Sébastien Dano, Goueh Gnahoui and Brou Jérôme Kablan

October 2011

Pure curcumin inhibits exogenous Wilms’ tumor (WT1) (+/+) isoform protein via degradation pathway and protein kinase C in transfected U937 cells

Wilms’ tumor (WT1) gene over expresses in leukemic cells which is alternatively spliced at two sites, yielding four isoforms: WT1 (+/+), (+/-), (-/+), and (-/-). Curcumin is one of major active components of the spice turmeric, widely known as anticancer. This study investigated the effects and inhibitory mechanism of pure curcumin on WT1 isoform-transfected U937 cells. WT1 transfected U937 cells were...

Author(s): Suwanna Semsri, Songyot Anuchapreeda, Nujeera Intasai, Tanyarat Jomgeow, Singkome Tima, Colleen Sweeney and Pornngarm Limtrakul

October 2011

Evaluation of methylation modification in E-cadherin gene and its application in the improvement of breast cancer

CDH1 (E-cadherin), which mediates cell-cell interaction and polarity, is known as glycoprotein in cytoskeleton. The objective of this study was to evaluate CDH1 expression loss as the metastatic marker by defining the methylation pattern in the promoter region and determining whether or not the methylation pattern changes in correlation with a kind of tumor, grade and metastatic status. Fifty patients with breast...

Author(s): Shohreh Alizadeh Shargh, Seyyed Mojtaba Mohaddes, Meral Sakizli, Jalal Gharesouran, Vahid Montazeri, Amir Vahedi and Fateme Karami

October 2011

Assessing the complexity of medicine regimens – A pilot study

Complexity of medication regimens may adversely affect adherence and treatment outcome. The aim of this study was to assess the complexity of medication regimens. In this retrospective study, complexity of the medication regimens for outpatients was assessed using the medication regimen complexity index (MRCI). The correlation between medication complexity and the parameters of age, gender, underlying disorder and the...

Author(s): Frasia Oosthuizen, Ebrahim Dhoodhat, Shaaista Kazi, Betty Masondo, Nasreen Omarjee, Zakhira Sacoor, Faadila Shaik and Dhiren Singh

October 2011

Anti-ulcer effect of Aloe vera in non-steroidal anti-inflammatory drug induced peptic ulcers in rats

This study was performed to determine the effects of Aloe vera on indomethacin induced ulcers in rats. Albino rats (Wister strain) of either sex weighing between 150 and 200 g were randomly allotted into four groups with six animals each. Indomethacin was administered orally in the dose of 20 mg/kg body weight and kept fasting for 6 h. A. vera powder was mixed with gum acacia, the solution was...

Author(s): Sai Krishna Borra, Radha Krishna Lagisetty and Gowrinath Reddy Mallela

October 2011

Correlation of the antioxidant capacity with the phenolic contents of Hypericum monogynum and Hypericum perforatum

This study was carried out to determine the total antioxidant activity and phenolic content of the two plants, that is, Hypericum monogynum and Hypericum perforatum. The antioxidant activities of both plants were carried out on the crude methanolic and subsequent solvent fractions in two concentrations, that is, 50 and 100 µg/ml. Among the tested samples, 80% methanolic and pure methanolic fractions...

Author(s): Niala Raziq, Naveed Muhammad, Kamran Ahmad Chishti, Muhammad Saeed, Shafiqur Rahman and Haroon Khan

October 2011

The evaluation of isotretinoin induced adverse drug reactions

Adverse drug reactions (ADRs) are a major cause of morbidity and mortality and have become one of the major health problems. So assessment, detection and monitoring of ADRs allow us to prevent and manage ADRs. Currently, isotretinoin is the effective therapy for the treatment of severe recalcitrant nodular acne unresponsive to conventional therapy. It can cause severe adverse reactions and teratogenic effects. So,...

Author(s): Taher Entezari-Maleki, Molouk Hadjibabaei, Jamshid Salamzadeh, Mohammad Reza Javadi, Gloria Shalviri and Kheirollah Gholami

October 2011

Design, formulation, optimization and evaluation of sustained release tablets of domperidone

Domperidone is widely used in the management of gastric disorders, particularly gastro esophageal reflux disorder and peptic ulcer. But the short half-life of domperidone leads to poor compliance and adverse reactions; that is why domperidone in sustained release dosage form is needed to achieve better therapeutic effects and to improve patient  compliance. For this purpose sustained release tablets of domperidone...

Author(s): Muhammad Asif Khan, Muhammad Saeed, Amir Badshah, Naveed Muhammad, Jahangir Khan, Farhat Ali Khan, Haroon Khan and Shafiq ur Rahman

October 2011

Effect of ciprofloxacin and levofloxacin on some oxidative stress parameters in brain regions of male albino rats

The present study aimed to investigate the possibility of involved oxidative stress due to the oral administration of either ciprofloxacin or levofloxacin (under therapeutic level) in the three brain regions, cerebral cortex, hippocampus and striatum of male albino rats weighing (100 ± 20 g). The ciprofloxacin and levofloxacin administered groups exhibited significant elevation in lipid peroxidation (LPO), nitric...

Author(s): Sayed M. Rawi, Iman M. Mourad, Nadia M. S. Arafa and Naema I. Alazabi

October 2011

Stability of anionic liposomes in serum and plasma

It is well-known that serum components destabilize liposomal membranes. Therefore, mostin-vitro transfection protocols avoid serum, which make the extrapolation to in-vivo situations difficult. In this study, we investigated the stability of different anionic liposomal formulations including artificial viral envelopes (AVEs) in 100% fetal calf serum (FCS), human serum (HS) and human plasma (HP) by...

Author(s): Mohsen Mahmoud Mady and Magdy Mohamed Ghannam

October 2011

Effect of rosmarinic acid on sexual behavior in diabetic male rats

One of the disorders that are caused by diabetes disease is reproductive problem, infertility and decrease libido. Antioxidants have essential effect on diabetes as enhanced oxidative stress, and changes in antioxidant capacity play an important role in the pathogenesis of chronic diabetes mellitus. So, the aim of this work was to study antioxidant effect of rosmarinic acid on sexual behavior of the diabetic rats....

Author(s): Laya Farzadi, Arash Khaki, Aleih ghasemzadeh, Elaheh Ouladsahebmadarek, Elham Ghadamkheir, Sina shadfar and Amir Afshin Khaki

October 2011

The effects of concurrent hydroalcoholic extract of Amaranthus caudatus L. and Hypericum perforatum L. of fatty streak formation in hypercholesterolemic animals

Hypercholesterolemia, a high cholesterol diet and oxidative stress increase serum low density lipoprotein (LDL) levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals, thus providing protection to humans against contagious and degenerative diseases. The aim of this study was to assess the anti-fatty streak effects of concurrent...

Author(s): Najmeh Kabiri, Sedigheh Asgary and Mahbubeh Setorki

October 2011

Hepatoprotective effect of methanolic extract of the leaves of Kydia calycina on carbon tetrachloride induced hepatotoxicity in albino rats

The hepatoprotective activity of methanolic extract of Kydia calycina (Malvaceae) (KCME) at doses of 250 and 500 mg/kg were evaluated by carbon tetrachloride (CCl4) intoxication inrats. The toxic group which received 1 ml/kg (50% CCl4 in olive oil) per oral, alone exhibited  significant increase in serum alanine transaminase (ALT), aspartate transaminase (AST),...

Author(s): H. Parameshwar, B. Babu Rao, B. Ravi Kumar, Y. Narsimha Reddy and G. Krishna Mohan

October 2011

Effects of acute exercise and aerobic exercise training on oxidative stress in young men and women

This research investigated the effect of acute exhaustive exercise and exercise training on thiobarbituric acid-reactive substances (TBARS), protein carbonyl (PC), total glutathione (GSH) levels and total superoxide dismutase (SOD) activities. Thirty-two healthy young men and women, 19 to 27 years old, who volunteered to participant in this study, underwent two months of endurance training. The training program...

Author(s): Hasan AKKUŞ

October 2011

Screening of eleven chemical constituents from Radix isatidis for antiviral activity

This study aimed to investigate the effects of eleven chemical constituents from Radix isatidis(Indigowoad root) on the inhibition of a mouse lung-adapted variant of the influenza A1 virus (FM1) and respiratory syncytial virus (RSV) in vitro and to identify the effective antiviral components of R. isatidis. The inhibitory effects of these chemical constituents against FM1 and RSV were measured...

Author(s): YE Wei-yang, LI Xiang and CHENG Jian-wei

October 2011

Brazilein overcame ABCB1-mediated multidrug resistance in human leukaemia K562/AO2 cells

Multidrug resistance (MDR) was still a major obstacle to the success of chemotherapy in cancer treatment. One of the underlying mechanisms of MDR was cellular overexpression of ABCB1 transporter which pumped various anticancer drugs out of the cells. Here, we investigated the anticancer activity of brazilein (a compound isolated from Caesalpinia sappanLinn.) against human leukaemia K562 and ABCB1 overexpression...

Author(s): Liyang Tao, Jianying Li and Jianye Zhang

October 2011

Grape seed extract mitigates high dosage garlic-induced toxic effects on erythrocyte and plasma parameters

High dosage garlic exerts adverse health properties and grape seed extract (GSE) exhibit a variety of beneficial effects, even at high dosage. In the present study we evaluated the toxic effect of high dosage garlic treatment on blood parameters and the protective effect of GSE co-treatment. Rats were intraperitoneally injected with 5 g/kg body weight (bw) crude garlic extract during one month and co-treated or not...

Author(s): Sonia Hamlaoui-Gasmi, Meherzia Mokni#, Nadia Limam, Ferid Limam, Mohamed Amri, Ezzedine Aouani and Lamjed Marzouki

October 2011

Evaluation of the effect of preemptive administration of Rosa damascena extract on post-operative pain in elective cesarean sections

Pain is the most common complaint in any kind of disorder. Despite its different nature, place and cause in various cases, pain is the main complaint of about half of the patients that are referred to physicians. Opiates and non-steroidal anti-inflammatory drugs, NSAIDS have been used for pain control many years ago, but these drugs also have some side effects. Regarding the complications and continuous pain...

Author(s): Parvin Mostafa Gharabaghi, Fatemeh Tabatabei, Sedigheh Abdollahi Fard, Manizheh Sayyah-Melli, Elaheh Ouladesahebmadarek Abbas Del Azar, Simin Atash Khoei, Manizheh Mostafa Gharabaghi, Morteza Ghojazadeh and Omid Mashrabi

October 2011

Assessment of sperm indices and testosterone level on the effect of Trichilia monadelpha extract in male albino rats

A lot of anti-malarial drugs are known to have serious detrimental effects on the sperm indices in experimental animals as well as in man; although recently, some drugs have been shown to have no adverse effects on testicular functions. The dearth of information on the reproductive toxicity of Trichilia monadelpha, a potent antimalarial plant in West Africa, especially in the South Western part of Nigeria, makes...

Author(s): O. T. Oyelowo, O. L. Bolarinwa and O. A. Morenikeji