Abstract

The hydro-alcoholic extract of Boerhaavia diffusa of leaves was investigated for evaluation of exhibited anxiolytic activity in rats at a dose 100 and 200 mg/kg by p.o. route for elevated plus maze test, hole-board test, haloperidol induced catalepsy and ketamine induced sleep method. Results of in vivo activity lead to the conclusion that the hydro-alcoholic of B. diffusashowed predominantly significant activity which is compared to the standard drug, diazepam (0.5 mg/kg).

Key words: Boerhaavia diffusa, anxiolytic activity, diazepam, haloperidol, hydro-alcoholic extract, ketamine, sleep.