African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 15 May, 2013; 7(18)

May 2013

Review on pharmacological activities of liriodenine

This review describes the pharmacological properties of liriodenine. This alkaloid has been isolated from plant species of many genera and exhibits a wide range of pharmacological activities that have been reported. This present paper enumerates an overview of pharmacological aspects that are useful to researchers for further exploration in order to develop the potential of this alkaloid.   Key...

Author(s): Chung-Yi Chen, Hui-Ming Wu, Wen-Ying Chao and Chien-Hsing Lee

May 2013

Evaluation of hydro-alcoholic extract of leaves of Boerhaavia diffusa for anxiolytic activity in rats

The hydro-alcoholic extract of Boerhaavia diffusa of leaves was investigated for evaluation of exhibited anxiolytic activity in rats at a dose 100 and 200 mg/kg by p.o. route for elevated plus maze test, hole-board test, haloperidol induced catalepsy and ketamine induced sleep method. Results of in vivo activity lead to the conclusion that the hydro-alcoholic of B. diffusashowed predominantly...

Author(s): Jitender Kumar Malik, Dayanand H. Gadekar and Sourabh Jain

May 2013

Pharmacists’ expectations regarding the services provided by drug and poison information center

Health care professionals have been surveyed concerning their satisfaction with Drug and Poison Information Centers’ (DPICs) services, but have rarely been questioned regarding their expectations. Knowing these expectations would be the starting point for improvement of DPIC’s services. As pharmacists are a major group of DPICs’ clients, this study was aimed to clarify the expectations of Iranian...

Author(s): Somayeh Hanafi, Mirhamed Hajimiri, Hassan Torkamandi, Alireza Hayatshahi and Mohammad Reza Javadi

May 2013

Calcium channel blockers attenuate chronic inflammation in rat knee joints

Previous studies demonstrated therapeutic effects for calcium channel blockers (CCBs) in control of acute inflammation. There are little reports on the effect of these blockers on chronic inflammation. In this study, we investigated the effects of CCBs on chronic inflammation using complete Ferund's adjuvant (CFA) induced inflammation in the rat knee joints. This experimental study was carried out on 80 male...

Author(s): Mohammad Reza Rahmani, Mohammad Allahtavakoli, Mehdi Mahmoodi, Gholamhossein Hassanshahi and Ali Shamsizadeh

May 2013

Osteoblastic activity of ethanolic extract and volatile compounds from Ee-Zhi-Wan, a famous traditional Chinese herbal formula

Er-Zhi-Wan (EZW), a famous traditional Chinese formula, which is comprised of the aerial parts of Eclipta prostrate L. (EP) (Astraceae) and the fruits of Ligustrum lucidum Ait. (FLL)(Oleaceae) has been developed as a restorative formula for hundreds of years. It is widely used to prevent and treat various kidney diseases. This study aimed to investigate the effects of volatile components and...

Author(s): Yan-Bin Wu, Jian-Guo Wu , Jun Yi , Ti-Qiang Chen , Xiong-Hao Lin  and Jin-Zhong Wu

May 2013

Effect of cultivation condition on the active component contents in Gentiana rigescens, a traditional Chinese medicine

The study aimed to determine the contents of secoiridoids activity compounds in different organs of Gentiana rigescens, and investigate the effects of growing age and cultivation method on the secoiridoids contents. The active compound contents in the root, the major medicinal part of G. rigescens, were higher than those in other organs. The active compounds contents in the leaf and flower were...

Author(s): Jinyu Zhang, Tao Shen, Yuanzhong Wang, Meiquan Yang, Ji Zhang, Shaobing Yang, Weize Yang, Yanli Zhao, Zhenling Zhao, Tianmei Yang and Hang Jin

May 2013

In vitro synergy and time-kill assessment of interaction between kanamycin and metronidazole against resistant bacteria

This study assessed the influence of combining kanamycin and metronidazole against Gram positive and Gram negative bacteria by agar diffusion, checkerboard and time-kill assays. The test isolates were highly resistant with minimum inhibitory concentrations (MICs) ranging between 15.63 and >250 µg/ml for kanamycin and between 15.63 and 125 µg/ml for metronidazole. The antibacterial combinations resulted in...

Author(s): OO Olajuyigbe,  and AJ Afolayan

May 2013

Analysis on 102 cases of adverse reactions caused by amoxicillin

To analyze the reports of adverse reactions caused by amoxicillin and explore its occurrence rules and characteristics. To collect the cases of adverse reactions caused by amoxicillin in the past five years in the hospital and make the statistical analysis. In the reports of the 102 cases of adverse reactions, the clinical manifestations were mainly skin and its accessory damage and systemic damage. Allergic reaction is...

Author(s): Ping Zang, Jin-Lan Liu, Fei Wang, Pei-Rong Zhang, Shu-Qin Chen and Hong Liu

May 2013

Combined treatment with resveratrol prevents the atorvastatin-induced myopathy in rat skeletal muscle

Statins are widely used besides their myopathic side effects, ranging from mild myalgia to fatal rhabdomyolysis. Resveratrol is one of the most popular over the counter products used for similar purposes with statins. The aim of this study was to elucidate the myopathic effects of atorvastatin and coadministered resveratrol in male rat skeletal muscle via morphological analyses and immunohistochemistry studies. Control...

Author(s): Burak Cem Soner, Salim Yalcin Inan, Ummu Güven, Gulperi Oktem and Ayse Saide Sahin

May 2013

Intravenous levetiracetam of hospitalized patients in Srinagarind Hospital

Levetiracetam (LEV) is a fairly new antiepileptic drug with broad effectiveness in controlling seizures. Presently, there is limited clinical data worldwide. This study aims to add more clinical efficacy and safety data for intravenous LEV. Chart review was done in patients who received intravenous LEV at Srinagarind Hospital, Khon Kaen University, Thailand from August, 2010 to June, 2012. There were 48 prescriptions on...

Author(s): Somsak Tiamkao, Suwaporn Thongplew, Sriwatree Chawsamtong and Kittisak Sawanyawisuth

May 2013

Pharmacokinetics of isoniazid in Ethiopian children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype

Until recently, the dose of isoniazid used to treat tuberculosis was the same for all patient groups. However, the pharmacokinetic profile of isoniazid varies across different populations. A comparative, observational, single-dose, 5 h study was conducted evaluating the pharmacokinetics of isoniazid in Ethiopian children. Pharmacokinetic parameters for a dose of 5 mg/kg and NAT2 genotype were determined in 29 children...

Author(s): Misgana Ibrahim, Ephrem Engidawork, Getnet Yimer, Kidist Bobosha and Abraham Aseffa

May 2013

Methylphenidate effects on search strategy of an animal model of attention-deficit/ hyperactivity disorder

This study is aimed at investigating the effects of methylphenidate about search strategy use on the spontaneously hypertensive rat, an animal model of attention-deficit/hyperactivity disorder in the Morris water maze. The methylphenidate group rats were given intraperitoneal injection of methylphenidate (10 mg/kg) dissolved in saline 30 min before daily training for 6 consecutive days. In the same way, the model...

Author(s): Yuan Tian, Yaping Wang, Hui Li, Dong Xu and Xinxin Ma.

May 2013

Effects of olanzapine versus risperidone on body mass index, serum leptin and lipid profile in schizophrenic patients

Weight gain is a common adverse effects associated with the use of some atypical antipsychotic drugs contributing to morbidity and poor adherence to treatment. Also, the antipsychotic treatment associated with increased levels of the hormone leptin and dyslipidemia. This study was conducted to investigate the influence of the two atypical antipsychotic drugs (olanzapine and risperidone) on body mass index (BMI), leptin...

Author(s): Musab M. Khalaf and Imad A. Thanoon