Full Length Research Paper
Abstract
The effect of salidroside (SD) on learning and memory ability of vascular dementia (VaD) rats were studied. The Wistar rats were randomly divided into six groups: Sham-operation group, VaD group, positive control (PC) group, SD high dose (SD-HD) treatment group, SD moderate dose (SD-MD) treatment group and SD low dose (SD-LD) treatment group. The bilateral common carotid arteries of Wistar rats were permanently ligated to established VaD models. The special study and memory were observed by Y-maze test. At postoperative 4, 8 and 12 weeks, error number (EN) and total reaction time (TRT) in the VaD, PC, SD-HD, SD-MD and SD-LD group were significantly more than those in the sham- operation group (P< 0.05 or 0.01), while EN and TRT in the PC, SD-HD, SD-MD and SD-LD groups were significantly less than those in the VaD group (P<0.05 or 0.01). Compared with PC group, EN and TRT in SD-MD and SD-LD groups were also higher (P<0.05 or 0.01). However, there were no significant differences in EN and TRT between PC and SD-HD groups (P>0.05). These results suggested that SD could improve the learning and memory ability of VaD rats by different dosages.
Key words: Salidroside, vascular dementia, rats.
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