African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2157

Table of Content: 29 January, 2012; 6(4)

January 2012

Alteration of the labeling of blood constituents with technetium-99m and the morphology of red blood cells by Baccharis trimera extract

Baccharis trimera (carqueja) has been used in folk medicine to treat rheumatism, diabetes and digestive disorders, and suggested as anti-inflammatory, analgesic, anti-ulcerative and antihepatotoxic. Blood constituents have been labeled with technetium-99m (99mTc) and used in nuclear medicine. The influence of natural and synthetic drugs in this procedure has been reported. In this work, the influence of an aqueous...

Author(s): Ana Cristina S. Braga, Maria Luisa Gomes, Josefina da Silva Santos, Joelma Fonseca de Oliveira, Eric Frederico Machado, Márcia Pereira Oliveira, Sebastião David Santos-Filho, and Mario Bernardo- Filho,

January 2012

Medetomidine elicit variable effects on sedative indices, hematological and physiological parameters in domestic pigeons (Columba livia)

The effects of graded doses of medetomidine (100, 150, 200 and 250 µg/kg) on hematology as well as physiological and sedative indices were evaluated in this study using domestic pigeons. Sedation ranging from sternal to lateral recumbency, as well as adequate muscle relaxation was observed. The longest sedative effect was observed using the highest dose which was statistically significant (P < 0.05) from the...

Author(s): Ismaila Muhammad Sani, and Kenneth Idowu Onifade

January 2012

Atorvastatin modulates constitutive and lipopolysaccharide induced IL-6 secretion in precursors of human skeletal muscle

It is well documented that, besides reducing blood LDL lipoproteins, HMG-CoA reductase inhibitors (statins) also suppress inflammatory markers and improve survival in sepsis. These beneficial effects can be at least partly explained by their capacity to inhibit the release of IL-6, which is generally regarded as a proinflammatory cytokine, although a variety of other actions including anti-inflammatory have...

Author(s): Alenka Golicnik, Matej Podbregar, Mitja Lainscak, Stefan D. Anker, Zoran Grubic and Tomaz Mars

January 2012

Effects of rosmarinic acid on male sex hormones (testosterone-FSH-LH) and testis tissue apoptosis after exposure to electromagnetic field (EMF) in rats

Rosmarinic acid (RA) is a polyphenol derived from many common herbal plants of the Lamiaceae group: Rosemary, sage, Spanish sage, oregano, basil, marjoram, thyme, the mint group, lavender, perilla and lemon balm. It is currently being studied for its effects on Alzheimer's disease and some other diseases. Rosmarinic acid in its natural state as part of a herb has been used to strengthen the memory and to improve...

Author(s): Arash Khaki, S. A. M. Imani and Farhad S. Golzar

January 2012

Evaluation of maternal and neonatal results after immediate labor induction by vaginal misoprostol and expectational treatment

Annual incidence of induced or strengthened labor in the United States, with nearly doubled increase, has risen from 20% in 1989 to 38% in 2002. For the success of labor induction, cervical status or its desirability is important. Different techniques are used to prepare the cervix. One of these techniques is using misoprostol tablets (Prostaglandin E1 (PGE1)). The aim of this study is to evaluate the maternal and...

Author(s): Talaat Dabbaghi Ghaleh, Fatemeh Lalooha, Rashin Normohammadi and Omid Mashrabi

January 2012

Development of in vitro-in vivo correlation for pharmacokinetic simulation

This article presents a comprehensive overview of systematic procedure for establishing and validating an in vitro - in vivo correlation (IVIVC) level A, B, and C. It encompasses all experimental, statistical and mathematical concepts of IVIVC development and its validation. A Level A IVIVC is an important mathematical tool that can help to save time and cost during and after the development of a...

Author(s): Ghulam Murtaza, Saira Azhar, Ayisha Khalid, Bushra Nasir, Muhammad Ubaid, Muhammad Khurran Shahzad, Fatima Saqib, Iftikhar Afzal, Sobia Noreen, Muhammad Tariq, Tahir Ali Chohan and Abdul Malik

January 2012

Effect of salidroside on learning and memory ability of vascular dementia rats

The effect of salidroside (SD) on learning and memory ability of vascular dementia (VaD) rats were studied. The Wistar rats were randomly divided into six groups: Sham-operation group, VaD group, positive control (PC) group, SD high dose (SD-HD) treatment group, SD moderate dose (SD-MD) treatment group and SD low dose (SD-LD) treatment group. The bilateral common carotid arteries of Wistar rats were permanently ligated...

Author(s): Wenjing Deng, Hong Lu, Xinwei Ren and Junfang Teng

January 2012

Characterization and pseudopolymorphism of l-phenylalanine anhydrous and monohydrate forms

In this work, the preformulation study on the solid state characterization for the anhydrous form and the monohydrate form of l-phenylalanine has been initially conducted by the use of powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and microscopy. Meanwhile, the solubility of both forms and the transformation...

Author(s): Jie Lu, Jing Wang, Zhen Li and Sohrab Rohani