African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Evaluation of surgical antimicrobial prophylaxis use in Ethiopia: Prospective study

Tamrat Legesse
  • Tamrat Legesse
  • Hawassa College of Health Sciences, Hawassa, Ethiopia.
  • Search for this author on:
  • Google Scholar
Desta Hiko
  • Desta Hiko
  • Department of Epidemiology, College of Health Sciences, Jimma University, Jimma, Ethiopia.
  • Search for this author on:
  • Google Scholar
Eneb Khelifa Ismael
  • Eneb Khelifa Ismael
  • Department of Pharmacy, College of Health Sciences, Madda Walabu University, Ethiopia.
  • Search for this author on:
  • Google Scholar
Sadikalmahdi Hussen Abdella
  • Sadikalmahdi Hussen Abdella
  • Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
  • Search for this author on:
  • Google Scholar


  •  Received: 04 January 2017
  •  Accepted: 20 July 2017
  •  Published: 22 December 2018

Abstract

Appropriate use of surgical antimicrobial prophylaxis can prevent approximately 40 to 60% of surgical site infections. Inappropriate  use  is  associated  with  emergency  of antimicrobial resistance,  occurrence  of  side  effects  and  increased  health  care  cost.  We aimed to evaluate surgical antimicrobial prophylaxis use of Hawassa University Referral Hospital against standard guideline Prospective  observational  study was done on  105  patients  who  undergone  major  surgical  procedure between  March 2 and  May 2,  2015.  Data was collected from patient medication charts, operational and anesthesia notes, by direct observation and patients’ interview using pre-tested questionnaire. All patients were followed daily before, during and after operation till discharge.  We  coded  and  cleaned  the  data  using  Epi-Data  version  3.1  and exported to SPSS for window version 20.0 software for analysis. Overall adherence to American society of health-system pharmacists (ASHP) for surgical antimicrobial prophylaxis use guideline was not observed for all parameters evaluated.  Surgical antimicrobial  prophylaxis  was  indicated  only  in  85(80.9%)  patients  but  administered  in  103  (98.1%) patients. Choice  of  antimicrobial  was  discordant  for  all  patients  for  whom  antimicrobial  prophylaxis  was indicated  and  administered.  Ceftriaxone  was  the  most  frequently  administered  73(70.9%)  antibiotics followed  by  combination  of  Ceftriaxone  and  Metronidazole  25(24.3%). Among 98.1% of patients who took antimicrobial  prophylaxis  ,  time  of  first  dose  administration and  duration  of administration were concordant in 38(36.9%) and 19(19.1%),  respectively.  Overall adherence to ASHP guideline was far from optimal for all parameters evaluated. 

Key words: Antimicrobial prophylaxis, American health system pharmacists, Ethiopia.

 

Abbreviation

SSI, Surgical site infection; HURH, Hawassa University Referral Hospital; JUSH, Jimma University Specialized Hospital; AMP, antimicrobial prophylaxis; AHSP, American Health System Pharmacists; SPSS, statistical package for social sciences

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 12 No. 31
Back to articles
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES