African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2195

Full Length Research Paper

Chemical composition, antibacterial and antioxidant activities of a new essential oil chemotype of Algerian Artemisia arborescens L.

Kawther Younes1, Salima Merghache1*, Nassim Djabou1,2, Djamila  Merghache3, Alain Muselli2, Boufeldja Tabti1 and Jean Costa2
1Laboratory of Natural and Bioactive substances (LASNABIO), Department of Chemistry, Faculty  of Sciences, University of Aboubekr Belkaïd, P. O. Box 119, Tlemcen 13000, Algeria. 2UMR CNRS 6134, Laboratory of Chemistry of Natural Products, University of Corse, P. O. Box 52, 20250 Corte, France. 3Antibiotic and Antifungal Physico-Chemistry, Synthesis and Biological Activity, Faculty  of Sciences of the Nature and the Life, University of Aboubekr Belkaïd, P. O. Box 119, Tlemcen 13000, Algeria.
Email: [email protected]

  •  Accepted: 16 May 2012
  •  Published: 15 November 2012

Abstract

The aim of the present study is to investigate the chemical composition, antibacterial and antioxidant activities of three essential oils extracted by hydrodistillation from the aerial parts ofArtemisia arborescens L., which was collected from three different regions near Tlemcen city in the West Northern of Algeria: Beni Snous, Bidar and Chetouane. The chemical composition was investigated using both capillary gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS) techniques. Fifty-two compounds were detected, a total of fifty compounds, representing 81.8 to 90.2% of the total oils were identified in the three samples of essential oils. The essential oils of A. arborescens were rich in camphor (Beni Snous: 72.2%, Bidar: 50.3% and Chetouane: 32.8%). The present composition of the essential oils, with camphor as the only most abundant component, was considered as a new chemotype of A. arborescens growing in West Northern of Algeria. Antibacterial activity of the essential oils against gram-positive and gram-negative bacteria, was tested using the diffusion method and by determining the inhibition zone. The results showed that the oils had a great potential antibacterial activity against some bacteria. The maximum zone of inhibition was obtained against Enterococcus faecalis (22 mm). In contrast, the oils were ineffective on the inactivation of Lysteria monocytogenes and Escherichia coli. Antioxidant capacity was assessed by in vitro tests using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and significant activity was found for these A. arborescens oils.

 

Key words: Artemisia arborescens L., Asteraceae, essential oil, chemical composition, chemotype, camphor, antibacterial activity, antioxidant activity.