African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2248

Full Length Research Paper

Synthesis and characterization of Cu(II) and Fe(II) metal complexes of oxazepine derivative via Schiff base [Fe(HPOHBOT)Cl2] and [Cu(HPOHBOT)Cl2]

Najim abbas Jabir Al awwadi
  • Najim abbas Jabir Al awwadi
  • Thi-qar University-College of Pharmacy, Iraq.
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Bassam Abdulhussein Hasan Alsafee
  • Bassam Abdulhussein Hasan Alsafee
  • Thi-qar University-College of Pharmacy, Iraq.
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Maitham Mohamed Abdulridha
  • Maitham Mohamed Abdulridha
  • Technical institute of Shatra, Iraq.
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  •  Received: 04 August 2016
  •  Accepted: 24 August 2016
  •  Published: 22 September 2016

Abstract

A Schiff base and its derivative (oxazepine) have been synthesized by the reaction between thio-semicarbazide and aromatic aldehyde 4-hydroxybenzaldehyde in ethanol in the presence of acetic acids to yield the Schiff base. This Schiff base on treatment with phthalic anhydride to give seven-member heterocyclic ring called oxazepine. Oxazepineas di-dentate ligand treated with hydrated metal chlorides CuCl2 and FeCl2 in the presence of ethanol as solvent to yield tetrahedral complexes. The structures of synthesized ligand and complexes have been established on the basis of their spectral Fourier transform infrared (FTIR), mass, 1H-NMR, elemental analysis C, H, N as well as molar conductance. The purity of the compounds was confirmed by thin layer chromatography (TLC).

Key words: Characterization, complexes, oxazepine, Schiff bases.