African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2205

Table of Content: 22 September, 2016; 10(35)

September 2016

Synthesis and characterization of Cu(II) and Fe(II) metal complexes of oxazepine derivative via Schiff base [Fe(HPOHBOT)Cl2] and [Cu(HPOHBOT)Cl2]

A Schiff base and its derivative (oxazepine) have been synthesized by the reaction between thio-semicarbazide and aromatic aldehyde 4-hydroxybenzaldehyde in ethanol in the presence of acetic acids to yield the Schiff base. This Schiff base on treatment with phthalic anhydride to give seven-member heterocyclic ring called oxazepine. Oxazepineas di-dentate ligand treated with hydrated metal chlorides CuCl2 and FeCl2 in...

Author(s): Najim abbas Jabir Al awwadi Bassam Abdulhussein Hasan Alsafee, and Maitham Mohamed Abdulridha

September 2016

Long term treatment of fluexotine and buspirone on gastric mucosal integrity in rats

The highly selective serotonin reuptake inhibitors are successful in the treatment of depression mood and anxiety disorders. The objective of this study is to investigate the effect of fluexotine and buspirone when given orally in three dose levels (5, 10 and 15 mg/ kg) not only for eight weeks on gastric lesions and oxidative markers in normal rats' mucosal integrity, but also for four weeks on gastric mucosal...

Author(s): Gehad A. Abdel-Jaleel, Nawal S. Gomaa, Azza A. Ali, Enaiat Omara and Ola A. Sharaf

September 2016

Ocular effects of oral acetazolamide on visual functions of normotensive individuals

Acetazolamide is a carbonic anhydrase inhibitor which is on World Health Organization’s list of essential medicines, a list of most important medications needed in a basic health system. The ocular effects of acetazolamide was studied in 30 normotensive volunteers. Each volunteer received a loading dose of 500 mg at 0700 h followed by a maintenance dose of 250 mg at 1300 and 1800 h, respectively on day one. From...

Author(s): Igwe S. A., Nwobodo N., Nwadike K., Agbata E. and Aneke B. N.