African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2245

Full Length Research Paper

The protective effects of Vitamin E and glibenclamide on spermatogenic and haematological changes in alloxan-induced diabetic male rats

R. I. Odo
  • R. I. Odo
  • Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.
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N. E. Ugwu
  • N. E. Ugwu
  • Department of Veterinary Surgery and Radiology, University of Nigeria, Nsukka, Nigeria.
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S. Akusu
  • S. Akusu
  • Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.
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  •  Received: 21 September 2018
  •  Accepted: 23 October 2018
  •  Published: 08 November 2018

Abstract

This study was designed to evaluate the preventive potentials of vitamin E and glibenclamide on spermatogenic and haematological damages in alloxan-induced diabetic male rats. Thirty mature male albino rats randomly assigned into 5 groups (n=6) were used for the study. Diabetes was experimentally induced in groups 1 to 4 while group 5 rats served as the negative control. Rats in groups 1, 2 and 3 were treated with glibenclamide, glibenclamide+Vitamin E, and Vitamin E, respectively while rats in group 4 served as the diabetic (positive) control. Results showed that percentage sperm motility was significantly higher (p<0.05) in groups 2 and 3 compared to group 1. Rats in group 2 recorded significant increases (p<0.05) in testicular weight, epididymal sperm reserve and testicular sperm reserve compared to groups 3 and 4, respectively. Rats of group 2 also had significantly higher packed cell volume and red blood cell counts compared to groups 1 and 3. Results from the study showed that combination of vitamin E and glibenclamide had optimum protective potential on the physiological parameters evaluated.

Key words: Diabetes, vitamin E, glibenclamide, spermatogenic changes, haematology, albino rats.