African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

The protective effects of Vitamin E and glibenclamide on spermatogenic and haematological changes in alloxan-induced diabetic male rats

R. I. Odo
  • R. I. Odo
  • Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.
  • Google Scholar
N. E. Ugwu
  • N. E. Ugwu
  • Department of Veterinary Surgery and Radiology, University of Nigeria, Nsukka, Nigeria.
  • Google Scholar
S. Akusu
  • S. Akusu
  • Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.
  • Google Scholar


  •  Received: 21 September 2018
  •  Accepted: 23 October 2018
  •  Published: 08 November 2018

References

AbuAbeeleh M, Bani Ismail Z, Alzaben KR, Abu-Halaweh SA, Al-Essa MK, Abu Abeeleh J (2009). Induction of Diabetes Mellitus in Rats Using Intraperitoneal Streptozotocin: A Comparison between 2 Strains of Rats. European Journal of scientific Research 32(3):398-2.

 

Amann RP (1986). Detection of alteration in testicular and epididymal function in laboratory animals. Environmental Health Perspectives. 70:119-158
Crossref

 

Anderson JE, Thliveris JA (1986). Testicular histology in streptozotocin-induced diabetes. Anatomical Record 214:378-382.
Crossref

 

Ashafa AOT, Yakubu MT, Grierson DS, Afolayan AJ (2009). Toxicological evaluation of the aqueous extract of Felicia muricata Thunb. leaves in Wistar rats. African Journal of Biotechnology 6(4):949-954.

 

Ballester J, Carmen Mu-oz M, Domínguez J, Rigau T, Guinovart J, Joan E, Rodríguez G (2004). Insulin-Dependent Diabetes Affects Testicular Function by FSH- and LH-Linked Mechanisms, Journal of Andrology 25(5):706-719.
Crossref

 

Brigelius-Flohe R, Traber MG (1999). Vitamin E: the shrew waiting to be tamed. Free Radical Biology and Medicine 46:543-554.
Crossref

 

Dacie JV, Lewis SM (1991). Practical Haematology, 7th Ed, Churchill Livingstone, Longman Group, UK. pp. 5-82.

 

Davidson IJ (2005). Canine diabetes mellitus: Can old dogs teach us new tricks. Diabetologica .

 

Gavazza MB, Catala A (2006). The effect of alpha-tocopherol on lipid peroxidation of microsomes and mitochondria from rat testis. Prostaglandins, Leukotrienes and Essential Fatty Acids 74: 247–254.
Crossref

 

Hotchkiss RS (1952). Etiology and Diagnosis in the treatment of infertility in males. Springfield, Illinois P 359.

 

Hurtado de Catalfo G, Nelva I, De Gómez Dumm T (1998). Lipid dismetabolism in Leydig and Sertoli cells isolated from streptozotocin-diabetic rats. International Journal of Biochemistry and Cell Biology 30:1001-1010.
Crossref

 

Kohen R, Nyska A (2002). Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicologic Pathology 30:620-630.
Crossref

 

Lucesoli F, Caligiuri M, Roberti MF, Perazzo JC, Fraga CG (1999). Dose-dependent increase of oxidative damage in the testes of rats subjected to acute iron overload. Archives of Biochemistry and Biophysics 372(1):37-43.
Crossref

 

Odo RI, Mbegbu EC, Ekere SO, Amaeze CF (2018). Hypoglycemic profile and ameliorative potential of aqueous garlic extract on sperm characteristics in glibenclamide treated diabetic male rats. African Journal of Pharmacy and Pharmacology 12(25):356-360.
Crossref

 

Olayemi FO (2010). A review on some causes of male infertility. African Journal of Biotechnology 9(20):2834-2842.

 

Orth JM, Murray FT, Bardin CW (1979). Ultrastructural changes in Leydig cells of streptozotocin-induced diabetic rats. The Anatomical Record 195:415-430.
Crossref

 

Oyedemi SO, Yakubu MT, Afolayan AJ (2011). Antidiabetic activities of aqueous leaves extract of Leonotis leonurus in streptozotocin induced diabetic rats. Journal of Medicinal Plant Research 5(1):119-125.

 

Paz G, Homonnai ZT (1979). Leydig cell function in streptozotocininduced diabetic rats. Experientia 35:1412-1413.
Crossref

 

Rand J, Marshall R (2005). Understanding feline diabetes mellitus; [Cited 2005 March 3]. 

 

Rother KI (2007). Diabetes Treatment - bridging the divide. The New England Journal of Medicine 356(15):1499-501.
Crossref

 

Schalm OW, Jari NC, Carol EJ (1975). Veterinary haematology, 3rd ed. Philadelphia, Pennysylvania, Lea and Febiger pp. 385-390.

 

Venugopal PM, Prince PSM, Pari L (1998). Hypoglycemic activity of Syzigium cumini seeds: effect on lipid peroxidation in alloxan diabetic rats. Journal of Ethnopharmacology 61:1-7.
Crossref

 

Ward JW, Elsea JR (1997). Animal case and use in drug fate and metabolism. Methods and techniques. In: Edward, R., G. and Jean, L.H, editors. Vol. 1. Markel Dekker, New York pp. 372-390.

 

Zhao Y, Dai J, Li B, Guo L, Cui J, Wang G, Shi X, Zhang X, Mellen N, Li W, Cai l (2011). Exacerbation of diabetes – induced testicular apoptosis by Zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p 53 activation in mice. Toxicology Letters pp. 100-106.
Crossref

 

Zimmermann M (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16(2):109-110.
Crossref