African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Effects of anti-hyperglicemic of yacon leaf (Smallanthus sonchifolius) ethanolic extracts using zebrafish as a model

Zuhelmi Aziz
  • Zuhelmi Aziz
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
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Nanda Tamara
  • Nanda Tamara
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
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Rahmi Three Wahyuni
  • Rahmi Three Wahyuni
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
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Inawati
  • Inawati
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
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Syamsudin Abdillah
  • Syamsudin Abdillah
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
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  •  Received: 21 February 2019
  •  Accepted: 16 May 2019
  •  Published: 22 May 2019

Abstract

This study aims to investigate the anti-hyperglicemic effects of yacon leaf (Smallanthus sonchifolius) using zebrafish. In this study, zebrafish is used as a model, with alloxan compounds to induce hyperglicemic. The induction stage consists of 3 phases: in the first the zebra was induced at 0.3% for 30 min, in the second stage, it was transferred to a 3% D-glucose solution for 30 min, and in the last, immersion was carried out in a solution containing yacon leaf extract with doses of 20, 30 and 40 mg/ml for 3 h in 3 consecutive days.The results showed that yacon leaf extract in doses of  20, 30 and 40 mg were able to reduce blood glucose levels in zebrafish induced by alloxan.The results indicated that 95% ethanolic extract has an antidiabetic effect.

Key words: Yacon leaf (Smallanthus sonchifolius), zebrafish, alloxan.

 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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