African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Effects of anti-hyperglicemic of yacon leaf (Smallanthus sonchifolius) ethanolic extracts using zebrafish as a model

Zuhelmi Aziz
  • Zuhelmi Aziz
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
  • Google Scholar
Nanda Tamara
  • Nanda Tamara
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
  • Google Scholar
Rahmi Three Wahyuni
  • Rahmi Three Wahyuni
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
  • Google Scholar
Inawati
  • Inawati
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
  • Google Scholar
Syamsudin Abdillah
  • Syamsudin Abdillah
  • Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia.
  • Google Scholar


  •  Received: 21 February 2019
  •  Accepted: 16 May 2019
  •  Published: 22 May 2019

References

Baroni S, Suzuki-Kemmelmeier F, Caparroz-Assef SM, Cuman RKN, Bersani-Amado CA (2008). Effect of crude extracts of leaves of Smallanthus sonchifolius (yacon) on glycemia in diabetic rats. Revista Brasileira de Ciências Farmacêuticas 44(3):521-530.
Crossref

 

Capiotti KM, Antonioli R, Kist LW, Bogo MR, Bonan CD, Da Silva RS (2014). Persistent impaired glucose metabolism in a zebrafish hyperglycemia model. Comp Biochem Physiol Part - B Biochemistry and Molecular Biology 171:58-65.
Crossref

 

Djamil R, Winarti W, Simanjuntak P (2014). Standardization and α-glycosidase inhibition of extracts of Vatica pauciflora Blume stem barks and Smallanthus sonchifolius leaves . Journal Pharmacognosy and Phytochemistry 3(4):42-46.

 

Dou DQ, Tian F, Qiu YK, Xiang Z, Xu BX, Kang TG (2010). Studies on chemical constituents of the leaves of Smallantus sonchifolius (yacon): Structures of two new diterpenes. Natural product research 24(1):40-47.
Crossref

 

Genta SB, Cabrera WM, Mercado MI, Grau A, Catalan CA, Sancheza SS (2010). Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius: constituents of the most active fractions. Chemico-Biological Interactions 185(2):143-152.
Crossref

 

International Diabetes Federation (IDF) (2015). Diabetes Atlas. 7th ed. Belgium: International Diabetes Federation, 2015. 

View

 

Kinkel MD, Prince VE (2009). On the diabetic menu: Zebrafish as a model for pancreas development and function Bioessays 31(2):139-152.
Crossref

 

Lawrence JM, Contreras R, Chen W, Sacks DA (2008). Trends in the prevalence of preexisting diabetes and gestational Diabetes mellitus among a racial diverse population of pregnant woment. Diabetes care 31(5):899-904.
Crossref

 

Shin E (2012) An optimal establishment of an acute hyperglycemia zebrafish model. African Journal of Pharmacy and Pharmacology 6(42):2922-2928.
Crossref

 

Stumwoll M, Goldstein BJ, Van Haeften TW ( 2005). Type-2 diabetes Principles of pathogenesis and therapy.The Lancet 365(9467):1333-1346.
Crossref

 

Wild S, Roglic G, Green A, Sicree R, King H (2004). Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-1053.
Crossref

 

World Health Organisation (WHO) (2016).. Global report on diabetes. 2016 

View

 

Zhang L, Shimada Y, Nishimura N (2017). Development of a Novel Zebrafish Model for type 2 Diabetes Mellitus. Scientific reports 7(1):1461.
Crossref

 

Zhang L, Maddison LA, Chen W (2018). Zebrafish as a model for obesity and diabetes. Frontiers in cell and developmental biology 6 p. 
Crossref