African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2165

Full Length Research Paper

Recent progress in the chemo-enzymatic peptide synthesis

Feifei Chen1, 2, Fangkai Zhang1, 3, Anming Wang1*, Haifeng Li1, Qiuyan Wang1, Zhaowu Zeng1, Shuling Wang1 and Tian Xie1
1Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou 310012, People’s Republic of China. 2College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, No. 222, Wenyi Road, Hangzhou 310012, People’s Republic of China. 3College of Biological and Environmental Sciences, Hangzhou Normal University, Hangzhou 310012, People’s Republic of China.
Email: [email protected]

  • Article Number - D0F174330100
  • Vol.4(10), pp. 721 - 730, October 2010
  •  Accepted: 13 October 2010
  •  Published: 31 October 2010


Peptides are molecules of paramount importance in several fields, especially in health care and nutrition. They have many beneficial health effects, such as antimicrobial, antiviral, antitumor, neuroactive and immunoactive activity. Several technologies for their production are now available such as chemical synthesis, biosynthesis and chemo-enzymatic peptide synthesis. For combining the advantages of chemical and enzymatic synthesis methods, chemo-enzymatic peptide synthesis has been attracting the interest of researchers in the peptide synthesis. In this paper, new progress in this method was reported. Enzymes, solvent systems and possible mechanisms were presented. The main strategies of chemo-enzymatic synthesis of peptides andmodification of enzymes by using different methods were also discussed.


Key words: Peptides, enzymes, solvent systems, chemo-enzymatic synthesis, genetic engineering, one-pot synthesis.

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